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Stephan A. Grupp
Researcher at Children's Hospital of Philadelphia
Publications - 396
Citations - 44427
Stephan A. Grupp is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Chimeric antigen receptor & Transplantation. The author has an hindex of 77, co-authored 366 publications receiving 34450 citations. Previous affiliations of Stephan A. Grupp include University of Pennsylvania & St. Jude Children's Research Hospital.
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CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia
Haydar Frangoul,David Altshuler,M. Domenica Cappellini,Yi-Shan Chen,Jennifer Domm,Brenda K. Eustace,Juergen Foell,Josu de la Fuente,Stephan A. Grupp,Rupert Handgretinger,Tony W. Ho,Antonis Kattamis,Andrew Kernytsky,Julie A. Lekstrom-Himes,Amanda M. Li,Franco Locatelli,Markus Y. Mapara,Mariane de Montalembert,Damiano Rondelli,Akshay Sharma,Sujit Sheth,Sandeep Soni,Martin H. Steinberg,Donna A. Wall,Angela Yen,Selim Corbacioglu +25 more
TL;DR: Electroporation of CD34+ hematopoietic stem and progenitor cells obtained from healthy donors was performed, with CRISPR-Cas9 targeting the BCL11A erythroid-specific enhancer, and approximately 80% of the alleles at this locus were modified, with no evidence of off-target editing.
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Mesenchymal stromal cell therapy induces high responses and survival in children with steroid refractory GVHD and poor risk biomarkers.
Stelios Kasikis,Janna Baez,Isha Gandhi,Stephan A. Grupp,Carrie L. Kitko,Steven Kowalyk,Pietro Merli,George Morales,Michael A. Pulsipher,Muna Qayed,Matthias Wölfl,Gregory A. Yanik,Fiona See,Jack Hayes,Fred Grossman,Elizabeth Burke,Rachel Young,John E. Levine,James L.M. Ferrara +18 more
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A novel antibody-TCR (AbTCR) T-cell therapy is safe and effective against CD19-positive relapsed/refractory B-cell lymphoma
Pengcheng He,Haibo Liu,Bryan Jeffrey Zimdahl,Jie Wang,Minna Luo,Q. Chang,Fang Tian,Fan Ni,Duo Yu,Hua-Sheng Liu,Limei Chen,Huaiyu Wang,Mei Zhang,Stephan A. Grupp,Cheng Liu +14 more
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Distinct Bioenergetic Features of Human Invariant Natural Killer T Cells Enable Retained Functions in Nutrient-Deprived States.
Priya Khurana,Chakkapong Burudpakdee,Stephan A. Grupp,Ulf H. Beier,Ulf H. Beier,Ulf H. Beier,David M. Barrett,Hamid Bassiri,Hamid Bassiri +8 more
TL;DR: In this article, a real-time Seahorse metabolic flux analysis revealed that human iNKT cells utilize fatty acids as substrates for oxidation more than conventional T cells. But, unlike TCONV, human iNs are not dependent upon glucose or glutamine for these effector functions and display higher mitochondrial mass and membrane potential relative to TCONVs.
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Prediction of Patients at Risk of CD19Neg Relapse Following CD19-Directed CAR T Cell Therapy in B Cell Precursor Acute Lymphoblastic Leukemia
Pablo Domizi,Astraea Jager,Jolanda Sarno,Charles G. Mullighan,Stephan A. Grupp,Elena Sotillo,David M. Barrett,Kara L. Davis +7 more
TL;DR: The hypothesis that resistant tumor cells are present before CAR-T administration and could be discovered and interrogated for CD19Neg relapse prediction is supported.