S
Stephan A. Grupp
Researcher at Children's Hospital of Philadelphia
Publications - 396
Citations - 44427
Stephan A. Grupp is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Chimeric antigen receptor & Transplantation. The author has an hindex of 77, co-authored 366 publications receiving 34450 citations. Previous affiliations of Stephan A. Grupp include University of Pennsylvania & St. Jude Children's Research Hospital.
Papers
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Journal ArticleDOI
Complete Responses in Patients with Autoimmune Lymphoproliferative Syndrome (ALPS) Using the mTOR Inhibitor Sirolimus (rapamycin)
Davi d T. Teachey,Robert J. Greiner,Dirk Schwabe,Jack J. Bleesing,Catherine S. Manno,Kathleen E. Sullivan,Daniel S. Wechsler,Stephan A. Grupp +7 more
TL;DR: Sirolimus significantly reduced the lymphoproliferative state and improved autoimmunity in patients with ALPS who had failed other therapies and should be considered as second line therapy for patients with steroid-refractory or steroid-intolerant disease.
Journal ArticleDOI
Reply to W.H. Tong et al.
Journal ArticleDOI
Abstract 909: Single-cell multi-omics reveals type-2 function and metabolic fitness in maintaining CAR T cell longevity associated with 8-year leukemia remission
TL;DR: Bai et al. as mentioned in this paper found that elevated type-2 functionality in both CD4+ and CD8+ subsets was associated with five patients maintaining a median B-cell aplasia duration of 8.4 years, which was independently validated using both intracellular flow cytometry and multiplexed secretomic assay.
Patent
Procedes de traitement de la leucemie lymphoide aigue
TL;DR: L'invention porte sur des procedes destines a traiter des patients atteints d'une leucemie lymphoide aigue precoce derivee des lymphocytes B avec la rapamycine ou un derive de celle-ci en combinaison avec un inhibiteur d'IL-7.