Stéphane Méthot

TL;DR: Maximum expression was obtained with a certain combination of DDA and MW that depended on N:P ratio and the pH, but similar expression levels could be achieved by simultaneously lowering MW and increasing DDA or lowering D DA and increasing MW, suggesting a predominant role of particle stability, through co-operative electrostatic binding, in determining transfection efficiency.

TL;DR: BST-CarGel® was shown to be an effective mid-term cartilage repair treatment and resulted in sustained and significantly superior repair tissue quantity and quality over microfracture alone at 5 years.

TL;DR: In this paper, the authors proposed guidelines for standardized histoprocessing and unbiased evaluation of animal tissues and human biopsies, which could improve statistical analyses, help interpret and validate noninvasive imaging outcomes, and permit cross-comparison between studies.

TL;DR: Repair tissues revealed the potential of microfracture-based repair procedures to produce zonal CO resembling native articular cartilage structure, which could benefit the development of cartilage repair strategies intended to recreate functional collagen architecture.

TL;DR: A new polarized light microscopy (PLM) score for collagen organization is developed and proposed that it be used to supplement current gold standard histological scoring systems for a more complete assessment of repair tissue quality.