S
Stéphane Moreau
Researcher at University of Bordeaux
Publications - 26
Citations - 496
Stéphane Moreau is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Quinoxaline & Candida albicans. The author has an hindex of 12, co-authored 26 publications receiving 381 citations. Previous affiliations of Stéphane Moreau include University of Auvergne & Centre national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: Synthesis, and in vitro antimalarial activity
Jean Guillon,Stéphane Moreau,Elisabeth Mouray,Véronique Sinou,Isabelle Forfar,Solene Belisle Fabre,Vanessa Desplat,Pascal Millet,Daniel Parzy,Christian Jarry,Philippe Grellier +10 more
TL;DR: Novel series of ferrocenic pyrrolo[1,2-a]quinoxaline derivatives 1-2 were synthesized from various substituted nitroanilines and tested for in vitro activity upon the erythrocytic development of Plasmodiumfalciparum strains with different chloroquine-resistance status.
Journal ArticleDOI
Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II
Vanessa Desplat,Stéphane Moreau,Solene Belisle Fabre,Denis Thiolat,Stéphane Massip,Gregory Macky,Frédéric Godde,Djavad Mossalayi,Christian Jarry,Jean Guillon +9 more
TL;DR: Preliminary biological results highlight the importance of substitution at the C-4 position of the pyrroloquinoxaline scaffold by a benzylpiperidinyl fluorobenzimidazole group, and also the need for a functionalization on thepyrrole ring.
Journal ArticleDOI
Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives.
Jean Guillon,Anita Cohen,Nassima Meriem Gueddouda,Rabindra Nath Das,Stéphane Moreau,Luisa Ronga,Solène Savrimoutou,Louise Basmaciyan,Alix Monnier,Myriam Monget,Sandra Rubio,Timothee Garnerin,Nadine Azas,Jean-Louis Mergny,Catherine Mullié,Pascal Sonnet +15 more
TL;DR: A novel series of bis- and tris-pyrrolo[1,2-a]quinoxaline derivatives 1 were synthesized and tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium falciparum strains, identifying the most potent antimalarial candidates with selectivity index (SI) of 40.6 on W2 strain, and 39.25 on 3D6 strain.
Journal ArticleDOI
Synthesis and evaluation of the cytotoxic activity of novel ethyl 4-[4-(4-substitutedpiperidin-1-yl)]benzyl-phenylpyrrolo[1,2-a]quinoxaline-carboxylate derivatives in myeloid and lymphoid leukemia cell lines
Vanessa Desplat,Marian Vincenzi,Marian Vincenzi,Romain Lucas,Stéphane Moreau,Solène Savrimoutou,Noël Pinaud,Jordi Lesbordes,Elodie Peyrilles,Mathieu Marchivie,Sylvain Routier,Pascal Sonnet,Filomena Rossi,Luisa Ronga,Jean Guillon +14 more
TL;DR: The new pyrrolo[1,2-a]quinoxaline series showed promising cytotoxic potential against all leukemia cell lines tested, and some compounds showed better results than the reference compound A6730.
Journal ArticleDOI
Synthesis and anticonvulsant properties of new benzylpyridazine derivatives.
Stéphane Moreau,Pascal Coudert,Catherine Rubat,Daniel Gardette,Danielle Vallee-Goyet,Jacques Couquelet,P. Bastide,P. Tronche +7 more
TL;DR: Results suggest that the pharmacological activity of 25 is partly due to modifications of glycinergic and GABAergic transmission, and molecular modeling studies based on the antiepileptic drug lamotrigine and the most stable conformer of 25 show structural similarities between these two molecules.