Stéphanie Ghislin

TL;DR: Analysis of femurs from mice embarked on board BION‐M1 biosatellite reveals a decrease in immune cell development, including B cells, after 1 wk of recovery on Earth, which may contribute to explain increased susceptibility to infection.

TL;DR: Data indicate that changing a mechanical force during ontogeny will likely affect host immunity because properties of loops constituting TCR antigen-binding sites are modified in hypergravity newborns, and the spectrum of peptides recognized by TCR will therefore likely be different.

TL;DR: Quantitative real-time PCR (qRT-PCR) demonstrated that under normal physiological conditions, P. waltl C3 mRNA is expressed early during development because it is likely required for neurulation, and its expression increased as the immune system developed.

TL;DR: The results suggest that C3 expression could be modified under real spaceflight conditions, potentially increasing the risk of inflammation and associated tissue damage.

TL;DR: Findings show that socioenvironmental stressors such as those encountered during space missions affect a fraction (25%) of the TCR‐β repertoire and that these stressors could increase self‐reactivity.