L
Laurence Vico
Researcher at University of Lyon
Publications - 226
Citations - 10619
Laurence Vico is an academic researcher from University of Lyon. The author has contributed to research in topics: Bone remodeling & Bone cell. The author has an hindex of 60, co-authored 208 publications receiving 9604 citations. Previous affiliations of Laurence Vico include Jean Monnet University & Sanofi S.A..
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Journal ArticleDOI
Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts
Laurence Vico,P. Collet,Alain Guignandon,Marie-Hélène Lafage-Proust,Thierry Thomas,Mohamed Rehailia,Christian Alexandre +6 more
TL;DR: In space, despite physical training, bone loss is an adaptive process that can become pathological after recovery on Earth, and striking interindividual variations in bone responses seem to suggest a need for adequate crew preselection.
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Mechanical Loading Down-Regulates Peroxisome Proliferator-Activated Receptor γ in Bone Marrow Stromal Cells and Favors Osteoblastogenesis at the Expense of Adipogenesis
Valentin David,Aline Martin,Marie-Hélène Lafage-Proust,Luc Malaval,Sylvie Peyroche,David Jones,Laurence Vico,Alain Guignandon +7 more
TL;DR: Evidence is provided that mechanical stimuli are potential PPARgamma modulators counteracting adipocyte differentiation and inhibition of osteoblastogenesis.
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Effects of 1- and 6-month spaceflight on bone mass and biochemistry in two humans
TL;DR: The lower weight-bearing bones appeared more sensitive than the upper ones in terms of spaceflight-induced bone loss, which probably explained the absence of marked systemic biochemical data changes.
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Effects of whole body vibration on the skeleton and other organ systems in man and animal models : What we know and what we need to know
Rhonda D. Prisby,Rhonda D. Prisby,Marie-Hélène Lafage-Proust,Marie-Hélène Lafage-Proust,Luc Malaval,Luc Malaval,Alain Belli,Laurence Vico,Laurence Vico +8 more
TL;DR: Findings focused on subject populations that may benefit most from such a therapy are reported in hopes of eliciting multidisciplinary scientific inquiries into this potentially therapeutic aid which presumably has global ramifications.
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Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis.
Luc Malaval,Ndéye Marième Wade-Gueye,Maya Boudiffa,Jia Fei,Ralph A Zirngibl,Frieda Chen,Norbert Laroche,Jean-Paul Roux,Brigitte Burt-Pichat,François Duboeuf,Georges Boivin,Pierre Jurdic,Marie-Hélène Lafage-Proust,Joëlle Amédée,Laurence Vico,Janet Rossant,Jane E. Aubin +16 more
TL;DR: It is reported that BSP−/− mice are viable and breed normally, but their weight and size are lower than wild-type (WT) mice, and BSP deficiency impairs bone growth and mineralization, concomitant with dramatically reduced bone formation.