Stephanie Hirn

TL;DR: The alterations of accumulation in the various organs and tissues, depending on GNP size and surface charge, are mediated by dynamic protein binding and exchange, which will improve drug delivery and dose estimates used in risk assessment.

TL;DR: It is shown that firmly grafted polymer shells around gold nanoparticles may degrade when injected into rats, and in vitro studies suggest that degradation of the polymer shell is caused by proteolytic enzymes in the liver.

TL;DR: The highest accumulation in secondary organs was mostly found for 1.4 nm particles; the negatively charged particles were accumulated mostly more than positively charged particles, and 18 nm particles show a higher accumulation in brain and heart compared to other sized particles.

TL;DR: The study shows that translocation across the ABB and accumulation and retention in secondary organs and tissues are two distinct processes, both depending specifically on particle characteristics such as SSA and surface charge.

TL;DR: Evidence of the potential toxicity and inflammogenic potential of Ag NPs in the liver following ingestion is presented and the similarities between in vitro and in vivo responses are striking and encouraging for future reduction, refinement, and replacement of animal studies by the use of hepatocyte cell lines in particle risk assessment.