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Eric S. Goetzman
Researcher at University of Pittsburgh
Publications - 71
Citations - 4722
Eric S. Goetzman is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Mitochondrion & Beta oxidation. The author has an hindex of 23, co-authored 58 publications receiving 3888 citations. Previous affiliations of Eric S. Goetzman include Boston Children's Hospital.
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Journal ArticleDOI
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Matthew D. Hirschey,Tadahiro Shimazu,Tadahiro Shimazu,Eric S. Goetzman,Enxuan Jing,Bjoern Schwer,Bjoern Schwer,Bjoern Schwer,David B. Lombard,Carrie A. Grueter,Charles A. Harris,Sudha B. Biddinger,Olga Ilkayeva,Robert Stevens,Yu Li,Asish K. Saha,Neil B. Ruderman,James R. Bain,Christopher B. Newgard,Robert V. Farese,Frederick W. Alt,C. Ronald Kahn,Eric Verdin,Eric Verdin +23 more
TL;DR: It is demonstrated that SIRT3 modulates mitochondrial intermediary metabolism and fatty-acid use during fasting and acetylation is identified as a novel regulatory mechanism for mitochondrial fatty- acid oxidation.
Journal ArticleDOI
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Matthew D. Hirschey,Tadahiro Shimazu,Enxuan Jing,Carrie A. Grueter,Amy M. Collins,Bradley E. Aouizerat,Alena Stančáková,Eric S. Goetzman,Maggie Lam,Bjoern Schwer,Robert Stevens,Michael J. Muehlbauer,Sanjay Kakar,Nathan M. Bass,Johanna Kuusisto,Markku Laakso,Frederick W. Alt,Frederick W. Alt,Christopher B. Newgard,Robert V. Farese,C. Ronald Kahn,Eric Verdin +21 more
TL;DR: It is found that high-fat diet (HFD) feeding induces hepatic mitochondrial protein hyperacetylation in mice and downregulation of the major mitochondrial protein deacetylase SIRT3, which contributes to the metabolic syndrome.
Journal ArticleDOI
Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice
Clara Bien Peek,Alison H. Affinati,Kathryn Moynihan Ramsey,Hsin Yu Kuo,Hsin Yu Kuo,Wei Yu,Laura A. Sena,Olga Ilkayeva,Biliana Marcheva,Yumiko Kobayashi,Chiaki Omura,Daniel C. Levine,David J. Bacsik,David Gius,Christopher B. Newgard,Eric S. Goetzman,Navdeep S. Chandel,John M. Denu,Milan Mrksich,Milan Mrksich,Joseph Bass +20 more
TL;DR: The results show that the circadian clock generates oscillations in mitochondrial oxidative capacity through rhythmic regulation of NAD+ biosynthesis, and facilitates oxidative rhythms that correspond with the fasting-feeding cycle to maximize energy production during rest.
Journal ArticleDOI
SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks
Matthew J. Rardin,Wenjuan He,Yuya Nishida,John C. Newman,Chris Carrico,Steven R. Danielson,Ailan Guo,Philipp Gut,Alexandria K. Sahu,Biao Li,Radha Uppala,Mark Fitch,Timothy Riiff,Lei Zhu,Jing Zhou,Daniel Mulhern,Robert Stevens,Olga Ilkayeva,Christopher B. Newgard,Matthew P. Jacobson,Marc K. Hellerstein,Eric S. Goetzman,Bradford W. Gibson,Bradford W. Gibson,Eric Verdin +24 more
TL;DR: Findings establish SIRT5 as a global regulator of lysine succinylation in mitochondria and present a mechanism for inhibition of ketogenesis through HMGCS2.
Journal ArticleDOI
Sirtuin 3 (SIRT3) Protein Regulates Long-chain Acyl-CoA Dehydrogenase by Deacetylating Conserved Lysines Near the Active Site
Sivakama S. Bharathi,Yuxun Zhang,Al-Walid Mohsen,Radha Uppala,Manimalha Balasubramani,Emanuel M. Schreiber,Guy Uechi,Megan E. Beck,Matthew J. Rardin,Jerry Vockley,Eric Verdin,Bradford W. Gibson,Matthew D. Hirschey,Eric S. Goetzman +13 more
TL;DR: The results suggest that acetylation/deacetylation at Lys-318/Lys-322 is a mode of regulating fatty acid oxidation and the same mechanism may regulate other acyl-CoA dehydrogenases.