C
Cynthia T. McMurray
Researcher at Lawrence Berkeley National Laboratory
Publications - 113
Citations - 8914
Cynthia T. McMurray is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Trinucleotide repeat expansion & Gene. The author has an hindex of 49, co-authored 111 publications receiving 8395 citations. Previous affiliations of Cynthia T. McMurray include Mayo Clinic & University of Rochester.
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Journal ArticleDOI
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair
Karl-Peter Hopfner,Lisa Craig,Gabriel Moncalián,Robert A. Zinkel,Takehiko Usui,Barbara A.L. Owen,Annette Karcher,Brendan Henderson,Jean Luc Bodmer,Cynthia T. McMurray,James P. Carney,John H.J. Petrini,John A. Tainer +12 more
TL;DR: Data support an architectural role for the Rad50 coiled coils in forming metal-mediated bridging complexes between two DNA-binding heads that have appropriate lengths and conformational properties to link sister chromatids in homologous recombination and DNA ends in non-homologous end-joining.
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Trinucleotide repeats that expand in human disease form hairpin structures in vitro
TL;DR: Hairpin formation provides a potential structural basis for the constancy of the CCG region of the Huntington's disease gene in individuals and explains the stabilizing effects of AGG interruptions in FMR1 alleles.
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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.
Eugenia Trushina,Roy B. Dyer,John D. Badger,Daren R. Ure,Lars Eide,Lars Eide,David Tran,Brent T. Vrieze,Valerie Legendre-Guillemin,Peter S. McPherson,Bhaskar S. Mandavilli,Bennett Van Houten,Scott Zeitlin,Mark A. McNiven,Ruedi Aebersold,Michael R. Hayden,Joseph E. Parisi,Erling Seeberg,Ioannis Dragatsis,Kelly Doyle,Anna Bender,Celin Chacko,Cynthia T. McMurray +22 more
TL;DR: Direct and functional evidence is provided that htt is involved in fast axonal trafficking in mammals and mhtt-mediated aggregation sequesters htt and components of trafficking machinery leading to loss of mitochondrial motility and eventual mitochondrial dysfunction.
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Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases
TL;DR: This review discusses similarities among HD, Friedreich ataxia and xeroderma pigmentosum, which provide insight into shared mechanisms of neuronal death, and focuses on Huntington's disease.
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Mechanisms of trinucleotide repeat instability during human development.
TL;DR: It is needed to connect the dots among human genetics, pathway biochemistry and the appropriate model systems to understand the mechanism of expansion as it occurs in human disease.