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Stephen A. Baldwin
Researcher at University of Leeds
Publications - 201
Citations - 13966
Stephen A. Baldwin is an academic researcher from University of Leeds. The author has contributed to research in topics: Nucleoside & Nucleoside transporter. The author has an hindex of 64, co-authored 201 publications receiving 13270 citations. Previous affiliations of Stephen A. Baldwin include University of Alberta & Cross Cancer Institute.
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Journal ArticleDOI
The equilibrative nucleoside transporter family, SLC29.
TL;DR: The human SLC29 family of proteins contains four members, designated equilibrative nucleoside transporters (ENTs) because of the properties of the first-characterised family member, hENT1, which possess similar broad substrate specificities for purine and pyrimidine nucleosides, but hENT2 in addition efficiently transports nucleobases.
Journal ArticleDOI
Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs
Mark Griffiths,Nick Beaumont,Sylvia Y.M. Yao,Manickavasagam Sundaram,Christine E. Boumah,Anthony Davies,Anthony Davies,Francis Y. P. Kwong,Imogen Coe,Carol E. Cass,James D. Young,Stephen A. Baldwin +11 more
TL;DR: The isolation of a human placental cDNA encoding a 456-residue glycoprotein with functional characteristics typical of an es-type transporter is reported, predicted to possess 11 membrane-spanning regions and is homologous to several proteins of unknown function in yeast, nematodes, plants and mammals.
Journal ArticleDOI
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants
Tamara J. Nicolson,Elisa A. Bellomo,Nadeeja Wijesekara,Merewyn K. Loder,Jocelyn M. Baldwin,Armen V. Gyulkhandanyan,Vasilij Koshkin,Andrei I. Tarasov,Raffaella Carzaniga,Katrin Kronenberger,Tarvinder K. Taneja,Gabriela da Silva Xavier,Sarah Libert,Philippe Froguel,Philippe Froguel,Raphael Scharfmann,Volodymir Stetsyuk,Philippe Ravassard,Helen E. Parker,Fiona M. Gribble,Frank Reimann,Robert Sladek,Stephen J. Hughes,Paul Johnson,Myriam Masseboeuf,Rémy Burcelin,Stephen A. Baldwin,Ming Liu,Roberto Lara-Lemus,Peter Arvan,Frans Schuit,Michael B. Wheeler,Fabrice Chimienti,Guy A. Rutter +33 more
TL;DR: ZnT8 is required for normal insulin crystallization and insulin release in vivo but not, remarkably, in vitro, and defects in the former processes in carriers of the R allele may increase type 2 diabetes risks.
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Nucleoside transporters: molecular biology and implications for therapeutic development.
TL;DR: The recent molecular characterization of two families of human nucleoside transporters has provided new insights into the mechanisms of natural nucleosides and drug uptake and into future developments of improved therapies.
Journal ArticleDOI
Molecular Identification and Characterization of Novel Human and Mouse Concentrative Na+-Nucleoside Cotransporter Proteins (hCNT3 and mCNT3) Broadly Selective for Purine and Pyrimidine Nucleosides (System cib)
Mabel W.L. Ritzel,Amy M. L. Ng,Sylvia Y.M. Yao,Kathryn Graham,Shaun K. Loewen,Kyla M. Smith,R. Gary Ritzel,Delores Mowles,Pat Carpenter,Xing-Zhen Chen,Edward Karpinski,Ralph J. Hyde,Stephen A. Baldwin,Carol E. Cass,James D. Young +14 more
TL;DR: The cDNA cloning and characterization of cib homologs of hfCNT from human mammary gland, differentiated human myeloid HL-60 cells, and mouse liver are reported, with results that indicate a sigmoidal dependence of uridine influx on Na+concentration indicated a Na+:uridine coupling ratio of at least 2:1 for both hCNT3 and mCNT2.