S
Stephen D. Bell
Researcher at Indiana University
Publications - 121
Citations - 8315
Stephen D. Bell is an academic researcher from Indiana University. The author has contributed to research in topics: DNA replication & Origin recognition complex. The author has an hindex of 54, co-authored 117 publications receiving 7874 citations. Previous affiliations of Stephen D. Bell include University of Oxford & Anderson University (Indiana).
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Journal ArticleDOI
The origin recognition complex in silencing, cell cycle progression, and dna replication
TL;DR: The silencing defect caused by orcs5-1 strengthened previous connections between ORC and silencing, and combined with the phenotypes caused by orc2 mutations, suggested that the complex itself functions in both processes.
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Mechanism and regulation of transcription in archaea.
TL;DR: The archaeal basal transcription machinery resembles the core components of the eucaryal RNA polymerase II apparatus and has given insight into the evolution of gene regulatory processes in all three domains of life.
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Evolution of diverse cell division and vesicle formation systems in Archaea
TL;DR: A comparative genomic analysis of the machineries for cell division and vesicle formation in Archaea suggests that the last common ancestor of the extant Archaea possessed a complex membrane remodelling apparatus, different components of which were lost during subsequent evolution of archaeal lineages.
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The Extracellular Matrix Protein TGFBI Induces Microtubule Stabilization and Sensitizes Ovarian Cancers to Paclitaxel
Ahmed Ashour Ahmed,Anthony D. Mills,Ashraf E.K. Ibrahim,Jillian Temple,Cherie Blenkiron,Maria Vias,Charles E. Massie,N. Gopalakrishna Iyer,Adam T. McGeoch,Robin Crawford,Barbara Nicke,Julian Downward,Charles Swanton,Stephen D. Bell,Helena M. Earl,Ronald A. Laskey,Carlos Caldas,James D. Brenton +17 more
TL;DR: The data show that ECM can mediate taxane sensitivity by modulating microtubule stability and that morphological changes of paclitaxel-induced cytotoxicity were restricted to areas of strong expression of TGFBI.
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Transcription and translation in Archaea: a mosaic of eukaryal and bacterial features
TL;DR: The principal components involved in the processes of transcription and translation in Archaea have been identified by a combination of biochemistry and genome sequencing and will shed considerable light on the evolution of gene regulatory processes.