S
Stephen D. Bell
Researcher at Indiana University
Publications - 121
Citations - 8315
Stephen D. Bell is an academic researcher from Indiana University. The author has contributed to research in topics: DNA replication & Origin recognition complex. The author has an hindex of 54, co-authored 117 publications receiving 7874 citations. Previous affiliations of Stephen D. Bell include University of Oxford & Anderson University (Indiana).
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Multiple consecutive initiation of replication producing novel brush-like intermediates at the termini of linear viral dsDNA genomes with hairpin ends
TL;DR: It is found that the rudivirus SIRV2 undergoes multiple consecutive replication reinitiation events at the genomic termini, which ensures rapid copying of the parental viral genome and will enable protein factors involved in viral genome replication to be specifically localised intracellularly, thereby helping the virus to avoid host defence mechanisms.
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Protein-protein interactions leading to recruitment of the host DNA sliding clamp by the hyperthermophilic Sulfolobus islandicus rod- shaped virus 2
TL;DR: In this paper, SIRV2 proteins were found to interact with proliferating cell nuclear antigen (PCNA), a key DNA replication protein in archaea, providing insights into the recruitment of host replisome for viral DNA replication.
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Archaeal DNA Replication.
Mark D. Greci,Stephen D. Bell +1 more
TL;DR: Recent advances in the field are described, highlighting conserved features and lineage-specific innovations in the archaeal domain of life.
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The glutamate switch is present in all seven clades of AAA+ protein.
TL;DR: In this paper, a highly conserved threonine residue was found to act as a glutamate switch in the replicative helicase, MCM, and showed that the glutamate switch is common in all seven AAA+ clades.
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Unique genome replication mechanism of the archaeal virus AFV1.
Mery Pina,Tamara Basta,Tessa E. F. Quax,Alexandra Joubert,Sonia Baconnais,Diego Cortez,Sarah Lambert,Eric Le Cam,Stephen D. Bell,Patrick Forterre,Patrick Forterre,David Prangishvili +11 more
TL;DR: An analysis of replicative intermediates of the viral genome by two‐dimensional agarose gel electrophoresis revealed that viral genome replication starts by the formation of a D‐loop and proceeds via strand displacement replication.