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Stephen D. Bell
Researcher at Indiana University
Publications - 121
Citations - 8315
Stephen D. Bell is an academic researcher from Indiana University. The author has contributed to research in topics: DNA replication & Origin recognition complex. The author has an hindex of 54, co-authored 117 publications receiving 7874 citations. Previous affiliations of Stephen D. Bell include University of Oxford & Anderson University (Indiana).
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Extrachromosomal element capture and the evolution of multiple replication origins in archaeal chromosomes
TL;DR: It is demonstrated that Aeropyrum pernix, a distant relative of Sulfolobus, has two origins, providing evidence that horizontal gene transfer, in addition to its well-established role in contributing to the information content of chromosomes, may fundamentally alter the manner in which the host chromosome is replicated.
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Genome-wide Analysis Reveals Extensive Functional Interaction between DNA Replication Initiation and Transcription in the Genome of Trypanosoma brucei
Calvin Tiengwe,Lucio Marcello,Helen Farr,Nicholas J. Dickens,Steven L. Kelly,Michal Swiderski,Diane Vaughan,Keith Gull,J. David Barry,Stephen D. Bell,Richard McCulloch +10 more
TL;DR: It is shown that replication and transcription in T. brucei have a profound functional overlap, as reducing ORC1/CDC6 levels leads to genome-wide increases in mRNA levels arising from the boundaries of the transcription units.
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Mechanism of autoregulation by an archaeal transcriptional repressor.
TL;DR: It is found that purified Lrs14 specifically represses the transcription of its own gene in a reconstituted in vitro transcription system, and it is shown that LRS14 binding sites overlap the basal promoter elements of the Lrp promoter and reveal that binding of Lrs 14 to these sites prevents promoter recognition by TATA box-binding protein and TFB.
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The archaeal TFIIEα homologue facilitates transcription initiation by enhancing TATA-box recognition
TL;DR: It is shown that, while TFE is not absolutely required for transcription in the reconstituted in vitro system, it nonetheless plays a stimulatory role on some promoters and under certain conditions.
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The Minichromosome Maintenance Replicative Helicase
TL;DR: The eukaryotic replicative helicase, the minichromosome maintenance (MCM) complex, is composed of six distinct, but related, subunits MCM(2-7).