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Stephen E Von Stetina
Researcher at Harvard University
Publications - 17
Citations - 1218
Stephen E Von Stetina is an academic researcher from Harvard University. The author has contributed to research in topics: Caenorhabditis elegans & Gene expression profiling. The author has an hindex of 13, co-authored 17 publications receiving 1102 citations. Previous affiliations of Stephen E Von Stetina include Vanderbilt University & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
A spatial and temporal map of C. elegans gene expression
W. Clay Spencer,Georg Zeller,Joseph D. Watson,Stefan R. Henz,Kathie L. Watkins,Rebecca McWhirter,Sarah C. Petersen,Vipin T. Sreedharan,Christian Widmer,Jeanyoung Jo,Valerie Reinke,Lisa N. Petrella,Susan Strome,Stephen E Von Stetina,Menachem Katz,Shai Shaham,Gunnar Rätsch,David M. Miller +17 more
TL;DR: By using cell-specific, whole-genome profiling strategies, a large number of novel transcripts are detected and high-resolution gene expression maps are produced that provide a basis for establishing the roles of individual genes in cellular differentiation.
Journal ArticleDOI
Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development.
TL;DR: The basic helix-loop-helix transcription factor Twist regulates a series of distinct cell fate decisions within the Drosophila mesodermal lineage and provides a paradigm for understanding how the same protein controls a sequence of events within a single lineage.
Journal ArticleDOI
acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction.
Denis Touroutine,Rebecca M. Fox,Stephen E Von Stetina,Anna O. Burdina,David M. Miller,Janet E. Richmond +5 more
TL;DR: Genetic ablation of both the levamisole-sensitive receptor and acr-16 abolished all cholinergic synaptic currents at the NMJ and severely impaired C. elegans locomotion, suggesting that ACR-16, like its closest vertebrate homolog, the nicotinic receptor α7-subunit, may form homomeric receptors in vivo.
Journal ArticleDOI
A gene expression fingerprint of C. elegans embryonic motor neurons
Rebecca M. Fox,Stephen E Von Stetina,Susan J Barlow,Christian M. Shaffer,Kellen L. Olszewski,Jason H. Moore,Denis Dupuy,Marc Vidal,David M. Miller +8 more
TL;DR: A microarray-based method, MAPCeL, is described for profiling gene expression in specific C. elegans motor neurons and evidence is provided that this approach can reveal candidate genes for key roles in the differentiation and function of these cells.
Journal ArticleDOI
Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system
Stephen E Von Stetina,Joseph D. Watson,Rebecca M. Fox,Rebecca M. Fox,Kellen L. Olszewski,Kellen L. Olszewski,W. Clay Spencer,Peter J. Roy,David M. Miller +8 more
TL;DR: Microarray-based strategies for generating expression profiles of embryonic and larval C. elegans neurons can be applied to particular neurons at specific developmental stages and, therefore, provide an unprecedented opportunity to obtain spatially and temporally defined snapshots of gene expression in a simple model nervous system.