K
Kellen L. Olszewski
Researcher at Princeton University
Publications - 36
Citations - 2661
Kellen L. Olszewski is an academic researcher from Princeton University. The author has contributed to research in topics: Glucose transporter & Plasmodium falciparum. The author has an hindex of 17, co-authored 30 publications receiving 1800 citations. Previous affiliations of Kellen L. Olszewski include Vanderbilt University.
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Journal ArticleDOI
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.
Chao Mao,Xiaoguang Liu,Yilei Zhang,Guang Lei,Yuelong Yan,Hyemin Lee,Pranavi Koppula,Pranavi Koppula,Shiqi Wu,Li Zhuang,Bingliang Fang,Masha V. Poyurovsky,Kellen L. Olszewski,Boyi Gan,Boyi Gan +14 more
TL;DR: In this article, the authors show that treatment of cancer cells with GPX4 inhibitors results in acute depletion of N-carbamoyl-L-aspartate, a pyrimidine biosynthesis intermediate, with concomitant accumulation of uridine.
Journal ArticleDOI
Host-parasite interactions revealed by Plasmodium falciparum metabolomics.
Kellen L. Olszewski,Joanne M. Morrisey,Daniel Wilinski,James M. Burns,Akhil B. Vaidya,Joshua D. Rabinowitz,Manuel Llinás +6 more
TL;DR: A mass spectrometry-based metabolomic analysis of the malaria parasite throughout its 48 hr intraerythrocytic developmental cycle reveals a general modulation of metabolite levels by the parasite, with numerous metabolites varying in phase with the developmental cycle.
Journal ArticleDOI
Specific DNA-binding by Apicomplexan AP2 transcription factors
Erandi K. De Silva,Andrew R. Gehrke,Kellen L. Olszewski,Ilsa León,Jasdave S. Chahal,Martha L. Bulyk,Manuel Llinás +6 more
TL;DR: The identification of the DNA-binding specificities for ApiAP2 proteins lays the foundation for the exploration of their role as transcriptional regulators during all stages of parasite development, which may prove to be ideal antimalarial targets.
Journal ArticleDOI
Identification and Genome-Wide Prediction of DNA Binding Specificities for the ApiAP2 Family of Regulators from the Malaria Parasite
TL;DR: A comprehensively surveyed DNA-binding specificities of all 27 members of the ApiAP2 protein family from Plasmodium falciparum revealing unique binding preferences for the majority of these DNA binding proteins and infer the trans-factors associated with previously reported plasmodial cis-elements.
Journal ArticleDOI
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.
Xiaoguang Liu,Kellen L. Olszewski,Yilei Zhang,Esther W. Lim,Jiejun Shi,Xiaoshan Zhang,Jie Zhang,Hyemin Lee,Pranavi Koppula,Pranavi Koppula,Guang Lei,Li Zhuang,M. James You,Bingliang Fang,Wei Li,Christian M. Metallo,Masha V. Poyurovsky,Boyi Gan,Boyi Gan +18 more
TL;DR: It is shown that cancer cells with high levels of SLC7A11 have increased dependency on the pentose phosphate pathway and consequently accumulate disulfide, and can be therapeutically targeted by limiting glucose supply.