S
Stephen Green
Researcher at French Institute of Health and Medical Research
Publications - 27
Citations - 10313
Stephen Green is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Estrogen receptor & Receptor. The author has an hindex of 22, co-authored 27 publications receiving 10196 citations.
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Journal ArticleDOI
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A
Stephen Green,P Walter,Vijay Kumar,Andrée Krust,Jean-Marc Bornert,Patrick Argos,Pierre Chambon +6 more
TL;DR: Cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7 and found extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.
Journal ArticleDOI
Functional domains of the human estrogen receptor.
TL;DR: Deletion of most or all of the hormone-binding domain leads to only about 5% constitutive transcriptional activity, yet these mutants appear to bind efficiently to an ERE in vivo.
Journal ArticleDOI
Nuclear receptors enhance our understanding of transcription regulation
Stephen Green,Pierre Chambon +1 more
TL;DR: Receptors for retinoic acid, vitamin D3 and the steroid and thyroid hormones belong to a family of ligand-activated enhancer-binding factors which are composed of a number of functional domains required for ligand and DNA binding, nuclear translocation, dimerization and trans -activation of transcription.
Journal ArticleDOI
Cloning of the human estrogen receptor cDNA.
P Walter,Stephen Green,Geoffrey L. Greene,Andrée Krust,Jean-Marc Bornert,Jean-Marc Jeltsch,A Staub,E V Jensen,Geoffrey T. Scrace,Michael D. Waterfield +9 more
TL;DR: Results demonstrate that the clones isolated correspond to the ER mRNA sequence, and use of lambda OR8 as a hybridization probe revealed a single poly(A)+ RNA band of approximately equal to 6.2 kilobase pairs in the ER-containing human breast cancer cell lines MCF-7 and T47D.
Journal ArticleDOI
The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors.
Andrée Krust,Stephen Green,Patrick Argos,Vijay Kumar,P Walter,Jean-Marc Bornert,Pierre Chambon +6 more
TL;DR: A chicken oviduct cDNA clone containing the complete open reading frame of the oestrogen receptor (ER) has been isolated and sequenced, indicating that c‐erbA, the cellular counterpart of v‐erbB, belongs to a multigene family of transcriptional regulatory proteins which bind steroid‐related ligands.