J
John P. Vella
Researcher at Maine Medical Center
Publications - 46
Citations - 3215
John P. Vella is an academic researcher from Maine Medical Center. The author has contributed to research in topics: Transplantation & Kidney transplantation. The author has an hindex of 21, co-authored 46 publications receiving 2993 citations. Previous affiliations of John P. Vella include Tufts University & Beaumont Hospital.
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Journal ArticleDOI
Germline mutations in the extracellular domains of the 55 kda tnf receptor, tnfr1, define a family of dominantly inherited autoinflammatory syndromes
Michael F. McDermott,Ivona Aksentijevich,Jérôme Galon,Elizabeth M. McDermott,B. William Ogunkolade,Michael Centola,Elizabeth Mansfield,Massimo Gadina,Leena Karenko,Tom Pettersson,John McCarthy,David M. Frucht,Martin Aringer,Yelizaveta Torosyan,Anna-Maija Teppo,Meredith Wilson,H.Mehmet Karaarslan,Ying Wan,Ian Todd,Geryl Wood,Ryan Schlimgen,Thisum R. Kumarajeewa,Sheldon M. Cooper,John P. Vella,Christopher I. Amos,John C. Mulley,Kathleen A. Quane,Michael G. Molloy,Annamari Ranki,Richard J. Powell,Graham A. Hitman,John J. O'Shea,Daniel L. Kastner +32 more
TL;DR: It is proposed that the autoinflammatory phenotype results from impaired downregulation of membrane TNFR1 and diminished shedding of potentially antagonistic soluble receptor inTNFR1-associated periodic syndromes.
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Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation
Bernd Krüger,Stefanie Krick,Navdeep Dhillon,Susan Lerner,Scott Ames,Jonathan S. Bromberg,Marvin Lin,Liron Walsh,John P. Vella,Michael Fischereder,Bernhard K. Krämer,Robert B. Colvin,Peter S. Heeger,Barbara Murphy,Bernd Schröppel +14 more
TL;DR: Previously undetected evidence that donor TLR4 contributes to graft inflammation and sterile injury following cold preservation and transplantation in humans is shown.
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Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction.
John P. Vella,Monica Spadafora-Ferreira,Barbara Murphy,Stephen I. Alexander,William E. Harmon,Charles B. Carpenter,Mohamed H. Sayegh +6 more
TL;DR: The hypothesis that T cells primed via the indirect pathway of allorecognition may be important mediators of chronic rejection is supported and the rationale to develop specific therapeutic strategies to prevent or interrupt this process is provided.
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Effect of renal transplantation on biomarkers of inflammation and oxidative stress in end-stage renal disease patients
Edith M. Simmons,Anthony Langone,M. Tugrul Sezer,John P. Vella,Peter Recupero,Jason D. Morrow,T. Alp Ikizler,Jonathan Himmelfarb +7 more
TL;DR: Findings indicate that restoration of renal function by transplantation improves the chronic inflammation and increased oxidative stress associated with uremia, which may contribute to the improved survival afforded to ESRD patients by renal transplantation.
Journal ArticleDOI
Hypertension After Kidney Transplant
Mahendra Mangray,John P. Vella +1 more
TL;DR: In conclusion, hypertension control affects both patient and long-term transplant survival, and its best management requires careful analysis of causes and close monitoring of therapies.