S
Stephen Tahan
Researcher at Washington University in St. Louis
Publications - 14
Citations - 1308
Stephen Tahan is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: RNA & Virus. The author has an hindex of 6, co-authored 11 publications receiving 636 citations.
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Journal ArticleDOI
Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.
Rita E. Chen,Xianwen Zhang,James Brett Case,Emma S. Winkler,Yang Liu,Laura A. VanBlargan,Jianying Liu,John M. Errico,Xuping Xie,Naveenchandra Suryadevara,Pavlo Gilchuk,Seth J. Zost,Stephen Tahan,Lindsay Droit,Jackson S. Turner,Wooseob Kim,Aaron J. Schmitz,Mahima Thapa,David Wang,Adrianus C. M. Boon,Rachel M. Presti,Jane A. O’Halloran,Alfred H.J. Kim,Parakkal Deepak,Dora Pinto,Daved H. Fremont,James E. Crowe,Davide Corti,Herbert W. Virgin,Herbert W. Virgin,Ali H. Ellebedy,Pei Yong Shi,Michael S. Diamond +32 more
TL;DR: In this article, using monoclonal antibodies (mAbs), animal immune sera, human convalescent sera and human sera from recipients of the BNT162b2 mRNA vaccine, the authors report the impact on antibody neutralization of a panel of authentic SARS-CoV-2 variants including a B.1.7 isolate, chimeric strains with South African or Brazilian spike genes and isogenic recombinant viral variants.
Journal ArticleDOI
Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2
James Brett Case,Paul W. Rothlauf,Paul W. Rothlauf,Rita E. Chen,Zhuoming Liu,Haiyan Zhao,Arthur S. Kim,Louis Marie Bloyet,Qiru Zeng,Stephen Tahan,Lindsay Droit,Ma. Xenia G. Ilagan,Michael A Tartell,Michael A Tartell,Gaya K. Amarasinghe,Jeffrey P. Henderson,Shane Miersch,Mart Ustav,Sachdev S. Sidhu,Herbert W. Virgin,David Wang,Siyuan Ding,Davide Corti,Elitza S. Theel,Daved H. Fremont,Michael S. Diamond,Sean P. J. Whelan +26 more
TL;DR: Two neutralizing activities of various antibodies and ACE2-Fc soluble decoy protein in both assays revealed a high degree of concordance, which will help define correlates of protection for antibody-based countermeasures and vaccines against SARS-CoV-2.
Journal ArticleDOI
Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2.
James Brett Case,Paul W. Rothlauf,Rita E. Chen,Zhuoming Liu,Haiyan Zhao,Arthur S. Kim,Louis Marie Bloyet,Qiru Zeng,Stephen Tahan,Lindsay Droit,Ma. Xenia G. Ilagan,Michael A Tartell,Gaya K. Amarasinghe,Jeffrey P. Henderson,Shane Miersch,Mart Ustav,Sachdev S. Sidhu,Herbert W. Virgin,David Wang,Siyuan Ding,Davide Corti,Elitza S. Theel,Daved H. Fremont,Michael S. Diamond,Sean P. J. Whelan +24 more
TL;DR: Two assays will help define correlates of protection for antibody-based countermeasures including therapeutic antibodies, immune γ-globulin or plasma preparations, and vaccines against SARS-CoV-2 and are compared to find an exceptionally high degree of concordance.
Posted ContentDOI
Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2
James Brett Case,Paul W. Rothlauf,Paul W. Rothlauf,Rita E. Chen,Zhuoming Liu,Haiyan Zhao,Arthur S. Kim,Louis Marie Bloyet,Qiru Zeng,Stephen Tahan,Lindsay Droit,Ma. Xenia G. Ilagan,Michael A Tartell,Michael A Tartell,Gaya K. Amarasinghe,Jeffrey P. Henderson,Shane Miersch,Mart Ustav,Sachdev S. Sidhu,Herbert W. Virgin,David Wang,Siyuan Ding,Davide Corti,Elitza S. Theel,Daved H. Fremont,Michael S. Diamond,Sean P. J. Whelan +26 more
TL;DR: Two assays will help define correlates of protection for antibody-based countermeasures including therapeutic antibodies, immune γ-globulin or plasma preparations, and vaccines against SARS-CoV-2.
Journal ArticleDOI
SARS-CoV-2 E Gene Variant Alters Analytical Sensitivity Characteristics of Viral Detection Using a Commercial Reverse Transcription-PCR Assay.
Stephen Tahan,Bijal A. Parikh,Lindsay Droit,Meghan A. Wallace,Carey-Ann D. Burnham,David Wang +5 more
TL;DR: In this paper, a G-to-U transversion was identified in the SARS-CoV-2 E gene in three specimens with reduced viral detection efficiency using a widely available commercial assay.