R
Rachel M. Presti
Researcher at Washington University in St. Louis
Publications - 95
Citations - 5754
Rachel M. Presti is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 26, co-authored 69 publications receiving 3364 citations. Previous affiliations of Rachel M. Presti include Saint Louis University.
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Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.
Rita E. Chen,Xianwen Zhang,James Brett Case,Emma S. Winkler,Yang Liu,Laura A. VanBlargan,Jianying Liu,John M. Errico,Xuping Xie,Naveenchandra Suryadevara,Pavlo Gilchuk,Seth J. Zost,Stephen Tahan,Lindsay Droit,Jackson S. Turner,Wooseob Kim,Aaron J. Schmitz,Mahima Thapa,David Wang,Adrianus C. M. Boon,Rachel M. Presti,Jane A. O’Halloran,Alfred H.J. Kim,Parakkal Deepak,Dora Pinto,Daved H. Fremont,James E. Crowe,Davide Corti,Herbert W. Virgin,Herbert W. Virgin,Ali H. Ellebedy,Pei Yong Shi,Michael S. Diamond +32 more
TL;DR: In this article, using monoclonal antibodies (mAbs), animal immune sera, human convalescent sera and human sera from recipients of the BNT162b2 mRNA vaccine, the authors report the impact on antibody neutralization of a panel of authentic SARS-CoV-2 variants including a B.1.7 isolate, chimeric strains with South African or Brazilian spike genes and isogenic recombinant viral variants.
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SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses.
Jackson S. Turner,Jane A. O’Halloran,Elizaveta Kalaidina,Wooseob Kim,Aaron J. Schmitz,Julian Q. Zhou,Tingting Lei,Mahima Thapa,Rita E. Chen,James Brett Case,Fatima Amanat,Adriana M Rauseo,Alem Haile,Xuping Xie,Michael K. Klebert,Teresa Suessen,William D. Middleton,Pei Yong Shi,Florian Krammer,Sharlene A. Teefey,Michael S. Diamond,Rachel M. Presti,Ali H. Ellebedy +22 more
TL;DR: In this article, the authors examined antigen-specific B-cell responses in peripheral blood and draining lymph nodes in 14 individuals who had received 2-doses of BNT162b2, an mRNA-based vaccine that encodes the full-length SARS-CoV-2 spike (S) gene1.
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Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs.
Todd A. Fehniger,Sheng F. Cai,Xuefang Cao,Andrew J. Bredemeyer,Rachel M. Presti,Anthony R. French,Timothy J. Ley +6 more
TL;DR: It is shown that resting murine NK cells contained abundant granzyme A, but little granzyme B or perforin; in contrast, the mRNAs for all three genes were abundant.
Journal ArticleDOI
Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii.
Ildiko Rita Dunay,Renato A. DaMatta,Blima Fux,Rachel M. Presti,Suellen Greco,Marco Colonna,L. David Sibley +6 more
TL;DR: Findings illustrate the critical importance of inflammatory monocytes as a first line of defense in controlling intestinal pathogens in mice susceptible to oral toxoplasmosis.
Journal ArticleDOI
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans.
Jackson S. Turner,Wooseob Kim,Elizaveta Kalaidina,Charles W. Goss,Adriana M Rauseo,Aaron J. Schmitz,Lena Hansen,Lena Hansen,Alem Haile,Michael K. Klebert,Iskra Pusic,Jane A. O’Halloran,Rachel M. Presti,Ali H. Ellebedy +13 more
TL;DR: In this paper, the authors show that mild SARS-CoV-2 infection induces long-lived bone marrow plasma cells that correlate with anti-SARS-coV2 spike protein antibody titres in individuals who have recovered from COVID-19.