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Steve Lacroix
Researcher at Laval University
Publications - 72
Citations - 6876
Steve Lacroix is an academic researcher from Laval University. The author has contributed to research in topics: Proinflammatory cytokine & Inflammation. The author has an hindex of 39, co-authored 67 publications receiving 5862 citations. Previous affiliations of Steve Lacroix include University of California, San Diego & McGill University.
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Journal ArticleDOI
Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved
Isabelle Pineau,Steve Lacroix +1 more
TL;DR: Results indicate that following SCI, all classes of neural cells initially contribute to the organization of inflammation, whereas recruited immune cells mostly contribute to its maintenance at later time points.
Journal ArticleDOI
Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation
Luc H. Boudreau,Anne Claire Duchez,Nathalie Cloutier,Denis Soulet,Nicolas Martin,James G. Bollinger,Alexandre Paré,Matthieu Rousseau,Gajendra S. Naika,Tania Lévesque,Cynthia Laflamme,Geneviève Marcoux,Gérard Lambeau,Richard W. Farndale,Marc Pouliot,Hind Hamzeh-Cognasse,Fabrice Cognasse,Olivier Garraud,Peter A. Nigrovic,Helga Guderley,Steve Lacroix,Louis Thibault,John W. Semple,Michael H. Gelb,Eric Boilard +24 more
TL;DR: It is shown that activated platelets release respiratory-competent mitochondria, both within membrane-encapsulated microparticles and as free organelles, at the midpoint of a potent mechanism leading to inflammatory responses.
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Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury.
Victor Bellver-Landete,Floriane Bretheau,Benoit Mailhot,Nicolas Vallières,Martine Lessard,Marie-Eve Janelle,Nathalie Vernoux,Marie-Ève Tremblay,Tobias Fuehrmann,Molly S. Shoichet,Steve Lacroix +10 more
TL;DR: It is shown that microglia are highly active and accumulate at the edge of the lesion in the first weeks post injury, and also that inhibiting microglian activation impairs recovery in the early stages after spinal cord injury.
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An Essential Role of Interleukin-1β in Mediating NF-κB Activity and COX-2 Transcription in Cells of the Blood–Brain Barrier in Response to a Systemic and Localized Inflammation But Not During Endotoxemia
TL;DR: It is indicated that IL-1β has an obligatory role in the activation of NF-κB molecules and PGs within endothelial cells of the BBB in an experimental model of intramuscularly turpentine-induced inflammation but not during endotoxemia.
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Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain.
Steve Lacroix,Serge Rivest +1 more
TL;DR: It is indicated that specific cell populations, in particular vascular‐ and/or perivascular‐associated cells, are responsible for the central production of prostaglandins during systemic inflammation, and circulating interleukin‐1β is likely to be a potent mediator of this response.