Steve M. Taylor

TL;DR: Haemoglobin AS, CC, and AC genotypes and homozygous and heterozygous α-thalassaemia provide significant protection from severe malaria syndromes, but these haemoglobinopathies differ substantially in the degree of protection provided and confer mild or no protection against uncomplicated malaria and asymptomatic parasitaemia.

TL;DR: An assay to quantify rare polymorphisms in parasite populations that uses a pooled deep-sequencing approach to score allele frequencies is developed and validated by evaluating mixtures of laboratory parasite strains, and used to screen P. falciparum parasites from >1100 African infections collected since 2002.

TL;DR: This Series paper summarises recent progress and highlights unresolved issues related to the burden of malaria in pregnancy and suggests pregnant women could be used to monitor malaria transmission.

TL;DR: This study describes the application of a resource-conserving testing algorithm employing sample pooling for real-time PCR assays for malaria in a cohort of 182 pregnant women in Kinshasa and highlights both substantial discordance between malaria diagnostics and the utility and parsimony of employing a sample Pooling strategy for molecular diagnostics in clinical and epidemiologic malaria studies.

TL;DR: The efficacy of SP to clear peripheral parasites and prevent new infections during pregnancy is compromised in areas with >90% prevalence of Pfdhps-K540E, and in these high-resistance areas, IPTp-SP use remains associated with increases in birth weight and maternal hemoglobin.