S
Steve M. Taylor
Researcher at Duke University
Publications - 105
Citations - 3347
Steve M. Taylor is an academic researcher from Duke University. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 30, co-authored 91 publications receiving 2727 citations. Previous affiliations of Steve M. Taylor include Durham University & Malawi-Liverpool-Wellcome Trust Clinical Research Programme.
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Journal ArticleDOI
Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis
TL;DR: Haemoglobin AS, CC, and AC genotypes and homozygous and heterozygous α-thalassaemia provide significant protection from severe malaria syndromes, but these haemoglobinopathies differ substantially in the degree of protection provided and confer mild or no protection against uncomplicated malaria and asymptomatic parasitaemia.
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Absence of Putative Artemisinin Resistance Mutations Among Plasmodium falciparum in Sub-Saharan Africa: A Molecular Epidemiologic Study
Steve M. Taylor,Steve M. Taylor,Christian M. Parobek,Derrick K. DeConti,Kassoum Kayentao,Sheick Oumar Coulibaly,Brian Greenwood,Harry Tagbor,John V. Williams,Kalifa Bojang,Fanta Njie,Meghna Desai,Simon Kariuki,Julie Gutman,Don P. Mathanga,Andreas Mårtensson,Billy Ngasala,Melissa D. Conrad,Philip J. Rosenthal,Antoinette Tshefu,Ann M. Moormann,John M. Vulule,Ogobara K. Doumbo,Feiko O. ter Kuile,Feiko O. ter Kuile,Steven R. Meshnick,Jeffrey A. Bailey,Jonathan J. Juliano +27 more
TL;DR: An assay to quantify rare polymorphisms in parasite populations that uses a pooled deep-sequencing approach to score allele frequencies is developed and validated by evaluating mixtures of laboratory parasite strains, and used to screen P. falciparum parasites from >1100 African infections collected since 2002.
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Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem
Stephen J. Rogerson,Meghna Desai,Alfredo Mayor,Alfredo Mayor,Elisa Sicuri,Elisa Sicuri,Steve M. Taylor,Anna Maria van Eijk +7 more
TL;DR: This Series paper summarises recent progress and highlights unresolved issues related to the burden of malaria in pregnancy and suggests pregnant women could be used to monitor malaria transmission.
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High-Throughput Pooling and Real-Time PCR-Based Strategy for Malaria Detection
Steve M. Taylor,Steve M. Taylor,Jonathan J. Juliano,Paul A. Trottman,Jennifer B. Griffin,Sarah H. Landis,Paluku Kitsa,Antoinette K. Tshefu,Steven R. Meshnick +8 more
TL;DR: This study describes the application of a resource-conserving testing algorithm employing sample pooling for real-time PCR assays for malaria in a cohort of 182 pregnant women in Kinshasa and highlights both substantial discordance between malaria diagnostics and the utility and parsimony of employing a sample Pooling strategy for molecular diagnostics in clinical and epidemiologic malaria studies.
Journal ArticleDOI
Impact of Sulfadoxine-Pyrimethamine Resistance on Effectiveness of Intermittent Preventive Therapy for Malaria in Pregnancy at Clearing Infections and Preventing Low Birth Weight
Meghna Desai,Meghna Desai,Julie Gutman,Steve M. Taylor,Steve M. Taylor,Ryan E. Wiegand,Carole Khairallah,Kassoum Kayentao,Kassoum Kayentao,Peter Ouma,Sheick Oumar Coulibaly,Linda Kalilani,Kimberly E. Mace,Emmanuel Arinaitwe,Don P. Mathanga,Ogobara K. Doumbo,Kephas Otieno,Dabira Edgar,Ebbie Chaluluka,Mulakwa Kamuliwo,Veronica Ades,Jacek Skarbinski,Ya Ping Shi,Pascal Magnussen,Steve Meshnick,Feiko O. ter Kuile +25 more
TL;DR: The efficacy of SP to clear peripheral parasites and prevent new infections during pregnancy is compromised in areas with >90% prevalence of Pfdhps-K540E, and in these high-resistance areas, IPTp-SP use remains associated with increases in birth weight and maternal hemoglobin.