J
Juan Carlos Tapia
Researcher at University of Concepción
Publications - 33
Citations - 2520
Juan Carlos Tapia is an academic researcher from University of Concepción. The author has contributed to research in topics: Glycine receptor & Motor neuron. The author has an hindex of 21, co-authored 33 publications receiving 2189 citations. Previous affiliations of Juan Carlos Tapia include University of Talca & Columbia University.
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Journal ArticleDOI
Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise
Gregorio Valdez,Juan Carlos Tapia,Hyuno Kang,Gregory D. Clemenson,Fred H. Gage,Jeff W. Lichtman,Joshua R. Sanes +6 more
TL;DR: A critical effect of aging on synaptic structure is demonstrated and evidence that interventions capable of extending health span and lifespan can partially reverse these age-related synaptic changes is provided.
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ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function
Aarti Sharma,Alex K. Lyashchenko,Lei Lu,Sara Ebrahimi Nasrabady,Margot Elmaleh,Monica Mendelsohn,Adriana Nemes,Juan Carlos Tapia,George Z. Mentis,Neil A. Shneider +9 more
TL;DR: It is demonstrated that FUS-dependent motor degeneration is not due to loss of FUS function, but to the gain of toxic properties conferred by ALS mutations.
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FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA
Tomohiro Yamazaki,Shi Chen,Yong Yu,Biao Yan,Tyler C. Haertlein,Monica A. Carrasco,Juan Carlos Tapia,Bo Zhai,Rita Das,Melanie Lalancette-Hebert,Aarti Sharma,Siddharthan Chandran,Gareth J. Sullivan,Agnes L. Nishimura,Christopher Shaw,Steve P. Gygi,Neil A. Shneider,Tom Maniatis,Robin Reed +18 more
TL;DR: The physical and functional interactions among SMN, FUS, TDP-43, and Gems indicate that ALS and SMA share a biochemical pathway, providing strong support for the view that these motor neuron diseases are related.
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Single-cell identity generated by combinatorial homophilic interactions between α, β, and γ protocadherins.
Chan Aye Thu,Weisheng V. Chen,Rotem Rubinstein,Maxime Chevee,Holly N. Wolcott,Klara Felsovalyi,Klara Felsovalyi,Klara Felsovalyi,Juan Carlos Tapia,Lawrence Shapiro,Barry Honig,Tom Maniatis +11 more
TL;DR: A theoretical analysis reveals that assembly of Pcdh isoforms into multimeric recognition units and the observed tolerance for mismatched isoforms can generate cell surface diversity sufficient for single-cell identity.
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Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
Isaac M. Chiu,Hemali Phatnani,Michael Kuligowski,Juan Carlos Tapia,Monica A. Carrasco,Ming Zhang,Tom Maniatis,Michael C. Carroll +7 more
TL;DR: Cross-talk between nervous and immune systems occurs throughout the PNS during ALS disease progression, revealing a progressive innate and humoral immune response in peripheral nerves that is separate and distinct from spinal cord immune activation in ALS transgenic mice.