H
Helmut Zarbl
Researcher at Rutgers University
Publications - 83
Citations - 4078
Helmut Zarbl is an academic researcher from Rutgers University. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 31, co-authored 83 publications receiving 3947 citations. Previous affiliations of Helmut Zarbl include Massachusetts Institute of Technology & McGill University.
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Journal ArticleDOI
Direct mutagenesis of Ha- ras -1 oncogenes by N -nitroso- N -methylurea during initiation of mammary carcinogenesis in rats
TL;DR: Each of the Ha-ras-1 oncogenes present in tumours induced by N-nitroso-N-methylurea, but not in those induced by 7,12-dimethylbenz(a)anthracene, became activated by the same G → A transition, the type of mutation induced by W → N → G → M transition.
Journal ArticleDOI
Standardizing global gene expression analysis between laboratories and across platforms
Theodore Bammler,Richard P. Beyer,Sanchita Bhattacharya,Gary A. Boorman,Abee L. Boyles,Blair U. Bradford,Roger E. Bumgarner,Pierre R. Bushel,Kabir Chaturvedi,Dongseok Choi,Michael L. Cunningham,Shibing Deng,Holly K. Dressman,Rickie D. Fannin,Fredrico M. Farin,Jonathan H. Freedman,Rebecca C. Fry,Angel Harper,Michael C. Humble,Patrick Hurban,Terrance J. Kavanagh,William K. Kaufmann,Kathleen F. Kerr,Li Jing,Jodi Lapidus,Michael R. Lasarev,Jianying Li,Yi-Ju Li,Edward K. Lobenhofer,Xinfang Lu,Renae L. Malek,Sean Milton,Srinivasa R. Nagalla,Jean P. O'Malley,Valerie S. Palmer,Patrick Pattee,Richard S. Paules,Charles M. Perou,Ken Phillips,Li-Xuan Qin,Yang Qiu,Sean D. Quigley,Matthew Rodland,Ivan Rusyn,Leona D. Samson,David A. Schwartz,Yan Shi,Jung Lim Shin,Stella O. Sieber,Susan H. Slifer,Marcy C. Speer,Peter S. Spencer,Dean I. Sproles,James A. Swenberg,William A. Suk,Robert C. Sullivan,Ru Tian,Raymond W. Tennant,Signe A. Todd,Charles J. Tucker,Bennett Van Houten,Brenda K. Weis,Shirley Xuan,Helmut Zarbl +63 more
TL;DR: In this paper, the authors proposed a method for standardizing global gene expression analysis between laboratories and across platforms, which can be found in Section 5.2.1.1].
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Mismatch amplification mutation assay (MAMA): application to the c-H-ras gene.
TL;DR: It is found that under appropriate conditions, an allele-specific polymerase chain reaction (PCR) can achieve a sensitivity suitable for measuring specific, infrequent mutations in single cell systems or in animal tissues.
Journal ArticleDOI
N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.
TL;DR: It is concluded that the NMU-induced mammary tumors carrying the G to A transition at the 12th codon of the Hras gene arose from preexisting ras mutants and that an independent effect of NMU was directly or indirectly responsible for tumor formation.
Journal ArticleDOI
Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues
Katy M. Olsavsky,Jeanine L. Page,Mary C. Johnson,Helmut Zarbl,Stephen C. Strom,Curtis J. Omiecinski +5 more
TL;DR: The robustness of the primary hepatocyte cultures was reflected by the extent of unchanged expression character when compared directly to liver, with more than 77% of the probe sets unchanged in each of the over-represented categories, representing such genes as C/EBPalpha, HNF4alpha, CYP2D6, and ABCB1.