S
Steven G. Thomas
Researcher at University of Birmingham
Publications - 59
Citations - 1823
Steven G. Thomas is an academic researcher from University of Birmingham. The author has contributed to research in topics: Cytoskeleton & Actin cytoskeleton. The author has an hindex of 21, co-authored 58 publications receiving 1555 citations. Previous affiliations of Steven G. Thomas include Utrecht University & University of Wolverhampton.
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Journal ArticleDOI
Self-incompatibility triggers programmed cell death in Papaver pollen.
TL;DR: It is shown that PCD is triggered by SI in an S-specific manner in incompatible pollen, providing a demonstration of a SI system using PCD, and revealing a novel mechanism to prevent self-fertilization.
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Actin depolymerization is sufficient to induce programmed cell death in self-incompatible pollen
TL;DR: It is demonstrated that changes in actin filament levels or dynamics play a functional role in initiating PCD in P. rhoeas pollen, triggering a caspase-3–like activity.
Journal ArticleDOI
Podosomes in adhesion, migration, mechanosensing and matrix remodeling
TL;DR: The structure and composition of podosomes and also their functions in various cell types of both myeloid and endothelial lineage are reviewed and the emerging idea that podosome can sense matrix stiffness and enable cells to respond to their environment is discussed.
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Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane
Hannah Schachtner,Simon D. J. Calaminus,Amy Sinclair,James Monypenny,Michael P. Blundell,Catherine Léon,Tessa L. Holyoake,Adrian J. Thrasher,Alison M. Michie,Milica Vukovic,Christian Gachet,Gareth E. Jones,Steven G. Thomas,Steve P. Watson,Laura M. Machesky +14 more
TL;DR: It is demonstrated for the first time a fundamental requirement for podosomes in megakaryocyte process extension across a basement membrane, and the results suggest that podosome may have a role in proplatelet arm extension or penetration of basement membrane.
Journal ArticleDOI
Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.
Natalie S. Poulter,Alice Y. Pollitt,Amy Davies,Dessislava Malinova,Gerard B. Nash,Michael J. Hannon,Zoe Pikramenou,Joshua Z. Rappoport,John H. Hartwig,Dylan M. Owen,Adrian J. Thrasher,Stephen P. Watson,Steven G. Thomas +12 more
TL;DR: It is proposed actin nodules are platelet podosome-related structures required for platelet–platelet interaction and their absence contributes to the bleeding diathesis of Wiskott–Aldrich syndrome.