H
Hannah Schachtner
Researcher at University of Glasgow
Publications - 5
Citations - 298
Hannah Schachtner is an academic researcher from University of Glasgow. The author has contributed to research in topics: Cytoskeleton & Podosome. The author has an hindex of 4, co-authored 5 publications receiving 266 citations.
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Journal ArticleDOI
Podosomes in adhesion, migration, mechanosensing and matrix remodeling
TL;DR: The structure and composition of podosomes and also their functions in various cell types of both myeloid and endothelial lineage are reviewed and the emerging idea that podosome can sense matrix stiffness and enable cells to respond to their environment is discussed.
Journal ArticleDOI
Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane
Hannah Schachtner,Simon D. J. Calaminus,Amy Sinclair,James Monypenny,Michael P. Blundell,Catherine Léon,Tessa L. Holyoake,Adrian J. Thrasher,Alison M. Michie,Milica Vukovic,Christian Gachet,Gareth E. Jones,Steven G. Thomas,Steve P. Watson,Laura M. Machesky +14 more
TL;DR: It is demonstrated for the first time a fundamental requirement for podosomes in megakaryocyte process extension across a basement membrane, and the results suggest that podosome may have a role in proplatelet arm extension or penetration of basement membrane.
Journal ArticleDOI
Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny
Simon D. J. Calaminus,Amelie V. Guitart,Amy Sinclair,Hannah Schachtner,Steve P. Watson,Tessa L. Holyoake,Kamil R. Kranc,Laura M. Machesky +7 more
TL;DR: It is demonstrated that Pf4-Cre also recombines in a significant proportion of both fetal liver and bone marrow hematopoietic stem cells (HSCs), including the most primitive fraction containing the long-term repopulating HSCs.
Journal ArticleDOI
Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo
Hannah Schachtner,Ang Li,David Stevenson,Simon D. J. Calaminus,Steven G. Thomas,Steve P. Watson,Michael Sixt,Roland Wedlich-Söldner,Douglas Strathdee,Laura M. Machesky +9 more
TL;DR: Through use of this conditionally inducible mouse model, insights are gained into the actin dynamics of cells that could only previously be studied using fixed specimens or following isolation from their native tissue environment.
Journal ArticleDOI
Correction: Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny
Simon D. J. Calaminus,Amelie V. Guitart,Amy Sinclair,Hannah Schachtner,Steve P. Watson,Tessa L. Holyoake,Kamil R. Kranc,Laura M. Machesky +7 more
TL;DR: The correct name of the second author is: Amelie V. Guitart, and the correct citation is: Calaminus SDJ, Guitarts AV, Sinclair A, Schachtner H, Watson SP, et al.