S
Steven H. Spoel
Researcher at University of Edinburgh
Publications - 54
Citations - 9535
Steven H. Spoel is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Proteasome & S-Nitrosylation. The author has an hindex of 30, co-authored 50 publications receiving 8316 citations. Previous affiliations of Steven H. Spoel include Duke University & Utrecht University.
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Journal ArticleDOI
NPR1 Modulates Cross-Talk between Salicylate- and Jasmonate-Dependent Defense Pathways through a Novel Function in the Cytosol
Steven H. Spoel,Steven H. Spoel,Annemart Koornneef,Susanne M. C. Claessens,Jerome Korzelius,Johan A. Van Pelt,Martin J. Mueller,Antony Buchala,Jean-Pierre Métraux,Rebecca L. Brown,Kemal Kazan,L.C. van Loon,Xinnian Dong,Corné M. J. Pieterse +13 more
TL;DR: Analysis of the Arabidopsis mutant npr1 revealed that the antagonistic effect of SA on JA signaling requires the regulatory protein NPR1, indicating that cross-talk between SA and JA is modulated through a novel function of NPR1 in the cytosol.
Journal ArticleDOI
Plant Immunity Requires Conformational Charges of NPR1 via S-Nitrosylation and Thioredoxins
Yasuomi Tada,Steven H. Spoel,Karolina M. Pajerowska-Mukhtar,Zhonglin Mou,Junqi Song,Chun Wang,Jianru Zuo,Xinnian Dong +7 more
TL;DR: It is reported that S-nitrosylation of NPR1 by S-Nitrosoglutathione at cysteine-156 facilitates its oligomerization, which maintains protein homeostasis upon SA induction, and suggest a link between pathogen-triggered redox changes and gene regulation in plant immunity.
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How do plants achieve immunity? Defence without specialized immune cells
Steven H. Spoel,Xinnian Dong +1 more
TL;DR: Recent developments point towards a multilayered plant innate immune system comprised of self-surveillance, systemic signalling and chromosomal changes that together establish effective immunity.
Journal ArticleDOI
NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants
Zheng Qing Fu,Shunping Yan,Abdelaty Saleh,Wei Wang,James Ruble,Nodoka Oka,Rajinikanth Mohan,Steven H. Spoel,Yasuomi Tada,Ning Zheng,Xinnian Dong +10 more
TL;DR: It is shown that the NPR1 paralogues NPR3 and NPR4 are SA receptors that bind SA with different affinities, and that this mutant is defective in pathogen effector-triggered programmed cell death and immunity.
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Regulation of tradeoffs between plant defenses against pathogens with different lifestyles
TL;DR: This work shows that plants tightly control cross-talk between SA- and JA-dependent defenses in a previously unrecognized spatial and pathogen type-specific fashion, which allows them to prevent unfavorable signal interactions and maximize their ability to concomitantly fend off multiple pathogens.