S
Steven Havlicek
Researcher at University of Erlangen-Nuremberg
Publications - 12
Citations - 626
Steven Havlicek is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Axoplasmic transport & Neurite. The author has an hindex of 9, co-authored 11 publications receiving 492 citations. Previous affiliations of Steven Havlicek include University of Würzburg & Genome Institute of Singapore.
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Journal ArticleDOI
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies
Iryna Prots,Janina Grosch,Razvan-Marius Brazdis,Katrin Simmnacher,Vanesa Veber,Steven Havlicek,Christian Hannappel,Florian Krach,Mandy Krumbiegel,Oliver Schütz,André Reis,Wolfgang Wrasidlo,Douglas Galasko,Teja W. Groemer,Eliezer Masliah,Eliezer Masliah,Ursula Schlötzer-Schrehardt,Wei Xiang,Jürgen Winkler,Beate Winner +19 more
TL;DR: In this article, the formation of oligomeric α-syn intermediates and reduced axonal mitochondrial transport in human neurons derived from induced pluripotent stem cells (iPSC) from a Parkinson's disease patient carrying an α-Syn gene duplication were demonstrated.
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Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients’ neurons
Steven Havlicek,Zacharias Kohl,Himanshu K. Mishra,Iryna Prots,Esther Eberhardt,Naime Denguir,Holger Wend,Sonja Plötz,Leah Boyer,Maria C. Marchetto,Stefan Aigner,Heinrich Sticht,Teja W. Groemer,Ute Hehr,Angelika Lampert,Ursula Schlötzer-Schrehardt,Jürgen Winkler,Fred H. Gage,Beate Winner +18 more
TL;DR: It is concluded that neurite complexity and maintenance in HSP patient-derived neurons are critically sensitive to spastin gene dosage and the human model offers an ideal platform for pharmacological screenings with the goal to restore physiological spASTin levels in SPG4 patients.
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The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal β-actin mRNA translocation in spinal motor neurons
Michael Glinka,Thomas Herrmann,Natalja Funk,Steven Havlicek,Wilfried Rossoll,Christoph Winkler,Michael Sendtner +6 more
TL;DR: The data suggest that hnRNP-R-mediated axonal beta-actin mRNA translocation plays an essential physiological role for axon growth and presynaptic differentiation.
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Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia
Francesc Pérez-Brangulí,Himanshu K. Mishra,Iryna Prots,Steven Havlicek,Zacharias Kohl,Domenica Saul,Christine Rummel,Jonatan Dorca-Arévalo,Martin Regensburger,Daniela Graef,Elisabeth Sock,Juan Blasi,Teja W. Groemer,Ursula Schlötzer-Schrehardt,Jürgen Winkler,Beate Winner +15 more
TL;DR: This study provides the first evidence that SPG11 is implicated in axonal maintenance and cargo trafficking, and investigates human pluripotent stem cell-derived neurons and mouse cortical neurons to corroborate spatacsin function.
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Laminin induced local axonal translation of β-actin mRNA is impaired in SMN-deficient motoneurons
TL;DR: It is suggested that local translation of β-actin in growth cones of motoneurons is regulated by Laminin signalling and that this signalling is disturbed in SMA.