D
Daniela Graef
Researcher at University of Erlangen-Nuremberg
Publications - 6
Citations - 366
Daniela Graef is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Autoantibody & Calnexin. The author has an hindex of 5, co-authored 6 publications receiving 252 citations.
Papers
More filters
Journal ArticleDOI
Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease.
Annika Sommer,Franz Marxreiter,Florian Krach,Tanja Fadler,Janina Grosch,Michele Maroni,Daniela Graef,Esther Eberhardt,Markus J. Riemenschneider,Gene W. Yeo,Zacharias Kohl,Wei Xiang,Fred H. Gage,Jürgen Winkler,Iryna Prots,Beate Winner +15 more
TL;DR: A role for human T lymphocytes as cell death inducers of induced pluripotent stem cell (iPSC)-derived MBNs in sporadic PD is shown and indicates a critical role for IL-17-producing T lymphocyte in sporadicPD.
Journal ArticleDOI
Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia
Francesc Pérez-Brangulí,Himanshu K. Mishra,Iryna Prots,Steven Havlicek,Zacharias Kohl,Domenica Saul,Christine Rummel,Jonatan Dorca-Arévalo,Martin Regensburger,Daniela Graef,Elisabeth Sock,Juan Blasi,Teja W. Groemer,Ursula Schlötzer-Schrehardt,Jürgen Winkler,Beate Winner +15 more
TL;DR: This study provides the first evidence that SPG11 is implicated in axonal maintenance and cargo trafficking, and investigates human pluripotent stem cell-derived neurons and mouse cortical neurons to corroborate spatacsin function.
Journal ArticleDOI
Antibodies to the endoplasmic reticulum-resident chaperones calnexin, BiP and Grp94 in patients with rheumatoid arthritis and systemic lupus erythematosus
Christian K Weber,Martin Haslbeck,Matthias Englbrecht,Bettina Sehnert,Dirk Mielenz,Daniela Graef,Jörg H W Distler,Ruediger B Mueller,Harald Burkhardt,Georg Schett,Reinhard E. Voll,Barbara G. Fürnrohr +11 more
TL;DR: Since calnexin, Grp94 and BiP are ER-resident proteins of eukaryotic cells, their data suggest that autoantibody generation against ER chaperones is independent of initial exposure to the corresponding bacterial chaperone; rather, ER chapersones may represent genuine autoantigens.
Journal ArticleDOI
Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus
Barbara G. Fürnrohr,Sven Wach,Jennifer A. Kelly,Martin Haslbeck,Christian K Weber,Christian Stach,Axel J. Hueber,Daniela Graef,Bernd M. Spriewald,K. Manger,Martin Herrmann,Kenneth M. Kaufman,Summer G. Frank,Ellen Goodmon,Judith A. James,Georg Schett,Thomas Winkler,John B. Harley,Reinhard E. Voll +18 more
TL;DR: Allelic variants of the Hsp70 genes are significantly associated with SLE in Caucasians, independently of HLA-DR3, and correlate with the presence of autoantibodies to Ro and La.
Journal ArticleDOI
Antibodies to the endoplasmic reticulum-resident chaperones calnexin, BiP and Grp94 in patients with rheumatoid arthritis and systemic lupus erythematosus
Christian K Weber,Martin Haslbeck,Matthias Englbrecht,Bettina Sehnert,Dirk Mielenz,Daniela Graef,J. H. W. Distler,Harald Burkhardt,Georg Schett,Reinhard E. Voll,Barbara G. Fürnrohr +10 more
TL;DR: To investigate the presence of autoantibodies against mammalian heat shock proteins of the endoplasmic reticulum (ER) in patients with rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis and inflammatory bowel disease,Sera from 40 healthy donors, 63 SLE patients, 22 Ssc patients, 14 patients with …