J
Jürgen Winkler
Researcher at University of Erlangen-Nuremberg
Publications - 153
Citations - 6123
Jürgen Winkler is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Neurogenesis & Gait analysis. The author has an hindex of 37, co-authored 145 publications receiving 4780 citations. Previous affiliations of Jürgen Winkler include University of Regensburg & Volkswagen Foundation.
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Journal ArticleDOI
Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease.
Annika Sommer,Franz Marxreiter,Florian Krach,Tanja Fadler,Janina Grosch,Michele Maroni,Daniela Graef,Esther Eberhardt,Markus J. Riemenschneider,Gene W. Yeo,Zacharias Kohl,Wei Xiang,Fred H. Gage,Jürgen Winkler,Iryna Prots,Beate Winner +15 more
TL;DR: A role for human T lymphocytes as cell death inducers of induced pluripotent stem cell (iPSC)-derived MBNs in sporadic PD is shown and indicates a critical role for IL-17-producing T lymphocyte in sporadicPD.
Journal ArticleDOI
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.
Edward Rockenstein,Silke Nuber,Cassia R. Overk,Kiren Ubhi,Michael Mante,Christina Patrick,Anthony Adame,Margarita Trejo-Morales,Juan Gerez,Paola Picotti,Poul Henning Jensen,Silvia Campioni,Roland Riek,Jürgen Winkler,Fred H. Gage,Beate Winner,Eliezer Masliah +16 more
TL;DR: The hypothesis that accumulating oligomeric α-synuclein may mediate early synaptic pathology in Parkinson's disease and dementia with Lewy bodies by disrupting synaptic vesicles is supported.
Journal ArticleDOI
Neurodegeneration and Motor Dysfunction in a Conditional Model of Parkinson's Disease
Silke Nuber,Elisabeth Petrasch-Parwez,Beate Winner,Jürgen Winkler,Stephan von Hörsten,Thorsten Schmidt,Jana Boy,M. Kuhn,Huu P. Nguyen,Peter Teismann,Jörg B. Schulz,Manuela Neumann,Bernd J. Pichler,Gerald Reischl,Carsten Holzmann,Ina Schmitt,Antje Bornemann,Wilfried Kuhn,Frank Zimmermann,Antonio Servadio,Olaf Riess +20 more
TL;DR: The data suggest that approaches targeting α-syn-induced pathological pathways might be of benefit rather in early disease stages, and α-Synuclein-associated cytotoxicity is independent of filamentous inclusion body formation in the authors' conditional mouse model.
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Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype
Georgia Minakaki,Stefanie Menges,Ágnes Kittel,Evangelia Emmanouilidou,Iris Schaeffner,Katalin Barkovits,Anna Bergmann,Edward Rockenstein,Anthony Adame,Franz Marxreiter,Brit Mollenhauer,Douglas Galasko,Edit I. Buzás,Ursula Schlötzer-Schrehardt,Katrin Marcus,Wei Xiang,Dieter Chichung Lie,Kostas Vekrellis,Eliezer Masliah,Jürgen Winkler,Jochen Klucken +20 more
TL;DR: Competing evidence is provided that a) ALP inhibition increases SNCA in neuronal EVs, b) distinct ALP components are present in EVs, and c) CSF EVs transfer S NCA from cell to cell in vivo is provided.
Journal ArticleDOI
Transforming growth factor-beta1 is a negative modulator of adult neurogenesis.
Frank-Peter Wachs,Beate Winner,Beate Winner,Sebastien Couillard-Despres,Sebastien Couillard-Despres,Thorsten Schiller,Thorsten Schiller,Robert Aigner,Robert Aigner,Jürgen Winkler,Jürgen Winkler,Ulrich Bogdahn,Ulrich Bogdahn,Ludwig Aigner,Ludwig Aigner +14 more
TL;DR: It is suggested that TGF-&bgr;1 is an important signaling molecule involved in the control of neural stem and progenitor cell proliferation in the CNS, which might have potential implications for neurogenesis in a variety of TGF -&b gr;1-associated CNS diseases and pathologic conditions.