M
Maria C. Marchetto
Researcher at Salk Institute for Biological Studies
Publications - 113
Citations - 15382
Maria C. Marchetto is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Induced pluripotent stem cell & Neural stem cell. The author has an hindex of 48, co-authored 102 publications receiving 13119 citations. Previous affiliations of Maria C. Marchetto include University of California, San Diego & University of São Paulo.
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Journal ArticleDOI
Mechanisms underlying inflammation in neurodegeneration.
TL;DR: There is evidence for a remarkable convergence in the mechanisms responsible for the sensing, transduction, and amplification of inflammatory processes that result in the production of neurotoxic mediators in neurodegenerative diseases.
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A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells
Maria C. Marchetto,Cassiano Carromeu,Allan Acab,Diana Yu,Gene W. Yeo,Yangling Mu,Gong Chen,Fred H. Gage,Alysson R. Muotri +8 more
TL;DR: The model recapitulates early stages of a human neurodevelopmental disease and represents a promising cellular tool for drug screening, diagnosis and personalized treatment and provides evidence of an unexplored developmental window, before disease onset, in RTT syndrome.
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Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
TL;DR: It is shown that an engineered human LINE-1 element can retrotranspose in neuronal precursors derived from rat hippocampus neural stem cells, indicating that neuronal genomes might not be static, but some might be mosaic because of de novo L1 retrotransposition events.
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L1 retrotransposition in neurons is modulated by MeCP2
Alysson R. Muotri,Maria C. Marchetto,Nicole G. Coufal,Ruth Oefner,Gene W. Yeo,Kinichi Nakashima,Fred H. Gage +6 more
TL;DR: It is shown that L1 neuronal transcription and retrotransposition in rodents are increased in the absence of methyl-CpG-binding protein 2 (MeCP2), a protein involved in global DNA methylation and human neurodevelopmental diseases and which patients with Rett syndrome, carrying MeCP2 mutations, have increased susceptibility for L1 retrotransposons.
Journal ArticleDOI
Drug screening for ALS using patient-specific induced pluripotent stem cells.
Naohiro Egawa,Shiho Kitaoka,Kayoko Tsukita,Motoko Naitoh,Kazutoshi Takahashi,Takuya Yamamoto,Fumihiko Adachi,Takayuki Kondo,Keisuke Okita,Isao Asaka,Takashi Aoi,Akira Watanabe,Yasuhiro Yamada,Asuka Morizane,Jun Takahashi,Takashi Ayaki,Hidefumi Ito,Katsuhiro Yoshikawa,Satoko Yamawaki,Shigehiko Suzuki,Dai Watanabe,Hiroyuki Hioki,Takeshi Kaneko,Kouki Makioka,Koichi Okamoto,Hiroshi Takuma,Akira Tamaoka,Kazuko Hasegawa,Takashi Nonaka,Masato Hasegawa,Akihiro Kawata,Minoru Yoshida,Tatsutoshi Nakahata,Ryosuke Takahashi,Maria C. Marchetto,Fred H. Gage,Shinya Yamanaka,Haruhisa Inoue +37 more
TL;DR: The new work provides an encouraging step toward using motor neurons generated from iPSCs derived from ALS patients to learn more about what triggers the death of motor neurons in this disease and to identify new candidate drugs that may be able to slow or reverse the devastating loss ofMotor neurons.