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Steven L. Walker
Researcher at Georgia Regents University
Publications - 12
Citations - 891
Steven L. Walker is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Zebrafish & Stem cell. The author has an hindex of 10, co-authored 11 publications receiving 784 citations. Previous affiliations of Steven L. Walker include The Chinese University of Hong Kong.
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Journal ArticleDOI
Mutations in CHD7, Encoding a Chromatin-Remodeling Protein, Cause Idiopathic Hypogonadotropic Hypogonadism and Kallmann Syndrome
Hyung Goo Kim,Ingo Kurth,Fei Lan,Irene Meliciani,Wolfgang Wenzel,Soo Hyun Eom,Gil Bu Kang,Georg Rosenberger,Mustafa Tekin,Metin Ozata,David P. Bick,Richard J. Sherins,Steven L. Walker,Yang Shi,James F. Gusella,Lawrence C. Layman +15 more
TL;DR: CHD7 represents the first identified chromatin-remodeling protein with a role in human puberty and the second gene to cause both normosmic IHH and KS in humans.
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Evaluating human cancer cell metastasis in zebrafish
TL;DR: The zebrafish model offers a rapid, robust, and inexpensive means of evaluating the metastatic potential of human cancer cells and is possible to critically evaluate whether genetic manipulation of signaling pathways affects metastasis and whether primary tumors contain metastatic cells.
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Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish.
Steven L. Walker,Junko Ariga,Jonathan R. Mathias,Veena Coothankandaswamy,Xiayang Xie,Martin Distel,Reinhard W. Köster,Michael J. Parsons,Kapil N. Bhalla,Meera Saxena,Jeff S. Mumm +10 more
TL;DR: ARQiv is a versatile and readily accessible approach facilitating evaluation of genetic and/or chemical manipulations in living zebrafish that complements current “high-content” whole-organism screening methods by providing a first-tier in vivo HTS drug discovery platform.
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First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass
Guangliang Wang,Surendra Kumar Rajpurohit,Fabien Delaspre,Steven L. Walker,David T. White,Alexis M Ceasrine,Rejji Kuruvilla,Ruo-Jing Li,Joong Sup Shim,Jun O. Liu,Michael J. Parsons,Jeff S. Mumm +11 more
TL;DR: These studies demonstrate the power of ARQiv-HTS for drug discovery and provide unique insights into signaling pathways controlling β-cell mass, potential therapeutic targets for treating diabetes.
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Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral phenotype
Yong Teng,Xiayang Xie,Steven L. Walker,Grzegorz A. Rempala,David J. Kozlowski,Jeff S. Mumm,John K. Cowell +6 more
TL;DR: The first model of genetically linked epilepsy in zebrafish is reported and an initial characterization of the behavioral and neurological phenotypes associated with morpholino (MO) knockdown of leucine-rich, glioma-inactivated 1a (lgi1a) expression is provided.