S
Stig Purup
Researcher at Aarhus University
Publications - 126
Citations - 4508
Stig Purup is an academic researcher from Aarhus University. The author has contributed to research in topics: Blastocyst & Somatic cell nuclear transfer. The author has an hindex of 37, co-authored 120 publications receiving 4014 citations. Previous affiliations of Stig Purup include Lund University.
Papers
More filters
Journal ArticleDOI
Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation.
Knud Erik Bach Knudsen,Helle Nygaard Lærke,Mette Skou Hedemann,Tina Skau Nielsen,Anne Krog Ingerslev,Ditte Søvsø Gundelund Nielsen,Peter Kappel Theil,Stig Purup,Stine Hald,Anne Grethe Schioldan,Maria L. Marco,Søren Gregersen,Kjeld Hermansen +12 more
TL;DR: The effect of butyrate seems generally to be more consistent and positive oninflammatory markers related to the gut than on inflammatory markers in the peripheral tissue, and this discrepancy may be explained by differences inbutyrate concentrations in the gut compared with the much lower concentration at more remote sites.
Journal ArticleDOI
Influence of prepubertal feeding level on milk yield potential of dairy heifers: a review.
Kristen Sejrsen,Stig Purup +1 more
TL;DR: Experimental evidence suggests that the observed negative effects of feeding level on subsequent milk are due to impaired mammary development, and development of suitable high growth rate feeding regimens for heifers requires understanding of the influence of nutrition on the physiological regulation of Mammary development.
Journal ArticleDOI
Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant
Rozh H Al-Mashhadi,Charlotte Brandt Sørensen,Peter M. Kragh,Christina Christoffersen,Martin Bødtker Mortensen,Lars Poulsen Tolbod,Troels Thim,Yutao Du,Juan Li,Ying Liu,Brian Moldt,Mette Schmidt,Gábor Vajta,Gábor Vajta,Torben Larsen,Stig Purup,Lars Bolund,Lars Bo Nielsen,Henrik Callesen,Erling Falk,Jacob Giehm Mikkelsen,Jacob F. Bentzon +21 more
TL;DR: This large-animal model will be important for better understanding the pathogenesis of familial hypercholesterolemia and for testing new therapeutics and imaging modalities before moving into human trials, and should prove useful for several types of translational research in atherosclerosis.
Journal ArticleDOI
Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer’s disease-causing dominant mutation APPsw
Peter M. Kragh,Anders Lade Nielsen,Juan Li,Yutao Du,Lin Lin,Mette Schmidt,I.B. Bøgh,Ida Elisabeth Holm,Jannik E. Jakobsen,Marianne Johansen,Stig Purup,Lars Bolund,Gábor Vajta,Arne Lund Jørgensen +13 more
TL;DR: High levels of transgene expression, including high level of the corresponding protein, was observed in brain tissue and not in heart or liver tissues, indicating accumulation of the Aβ peptide in the brain may develop at the age of 1–2 years.
Journal ArticleDOI
High body weight gain and reduced bovine mammary growth: physiological basis and implications for milk yield potential
TL;DR: The investigations suggest that blood growth hormone (GH) is important for mammary development, and that the negative effect of high feeding level on Mammary development may be due to reduced blood GH, however, GH does not bind to mammary tissue.