Mette Schmidt

TL;DR: Under defined culture conditions, addition of citrate and myo-inositol improved blastocyst development to rates comparable to those obtained with serum, BSA or co-culture and that the quality of blastocysts was not affected by the absence of serum or BSA.

TL;DR: Germ-free conditions and antiserum against Clostridium perfringens toxin prevented intestinal dysfunction and NEC in formula-fed pigs, whereas the gut trophic factors, epidermal growth factor, and glucagon-like peptide 2 had limited effects.

TL;DR: The preterm pig model is presented as a translational model in pediatric gastroenterology that has provided new insights into important pediatric diseases such as NEC and SBS and may also provide a sensitive model for postnatal adaptation of weak term piglets showing high mortality.

TL;DR: This large-animal model will be important for better understanding the pathogenesis of familial hypercholesterolemia and for testing new therapeutics and imaging modalities before moving into human trials, and should prove useful for several types of translational research in atherosclerosis.

TL;DR: It is concluded that GLP-2 increases intestinal growth in premature, TPN-fed pigs by decreasing proteolysis and apoptosis, whereas enteral nutrition acts via increased protein synthesis and cell proliferation and decreased apoptosis.