S
Stine Thorhauge Zwisler
Researcher at Odense University Hospital
Publications - 29
Citations - 570
Stine Thorhauge Zwisler is an academic researcher from Odense University Hospital. The author has contributed to research in topics: Oxycodone & Medicine. The author has an hindex of 9, co-authored 26 publications receiving 454 citations. Previous affiliations of Stine Thorhauge Zwisler include University of Southern Denmark.
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Journal ArticleDOI
The Hypoalgesic Effect of Oxycodone in Human Experimental Pain Models in Relation to the CYP2D6 Oxidation Polymorphism
Stine Thorhauge Zwisler,Stine Thorhauge Zwisler,Thomas P. Enggaard,Thomas P. Enggaard,Lene Noehr-Jensen,Rasmus Steen Pedersen,Soeren Mikkelsen,Flemming Nielsen,Kim Brøsen,Soeren H. Sindrup +9 more
TL;DR: Oxycodone analgesia seems to depend both on oxycodone itself and its metabolite oxymorphone, which is a potent micro-receptor agonist.
Journal ArticleDOI
The antinociceptive effect and adverse drug reactions of oxycodone in human experimental pain in relation to genetic variations in the OPRM1 and ABCB1 genes
Stine Thorhauge Zwisler,Stine Thorhauge Zwisler,Thomas P. Enggaard,Thomas P. Enggaard,Lene Noehr-Jensen,Soeren Mikkelsen,Céline Verstuyft,Laurent Becquemont,Soeren H. Sindrup,Kim Brøsen +9 more
TL;DR: There was strong association between less antinociceptive effect of oxycodone and the variant alleles of C3435T and G2677T/A and a moderate association between more severe adverse drug reactions than the carriers of the variant allele of A118G.
Journal ArticleDOI
Impact of the CYP2D6 genotype on post-operative intravenous oxycodone analgesia.
Stine Thorhauge Zwisler,Stine Thorhauge Zwisler,Thomas P. Enggaard,Thomas P. Enggaard,Søren Mikkelsen,Kim Brøsen,Søren H. Sindrup +6 more
TL;DR: This study investigated whether CYP2D6 poor metabolizer (PMs) yield the same analgesia post‐operatively from intravenous oxycodone as extensive metabolizers (EMs).
Journal ArticleDOI
Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients with In-Hospital Cardiac Arrest: A Randomized Clinical Trial
Lars W. Andersen,Dan Lou Isbye,Jesper Kjaergaard,Camilla Meno Kristensen,S. Darling,Stine Thorhauge Zwisler,Stine Fisker,Jens Christian Schmidt,Hans Kirkegaard,Anders Morten Grejs,Jørgen R.G. Rossau,Jacob Moesgaard Larsen,Bodil Steen Rasmussen,Signe Riddersholm,Kasper Iversen,Martin Schultz,Jakob L. Nielsen,Bo Løfgren,Kasper G Lauridsen,Christoffer Sølling,Kim B. Pælestik,Anders G. Kjærgaard,Dorte Due-Rasmussen,Fredrik Folke,Mette Charlot,Rikke Malene H.G. Jepsen,Sebastian Wiberg,Michael W. Donnino,Tobias Kurth,Maria Høybye,Birthe Sindberg,Mathias J. Holmberg,Asger Granfeldt +32 more
TL;DR: In this article, the authors evaluated whether the combination of vasopressin and methylprednisolone administered during in-hospital cardiac arrest improves the return of spontaneous circulation in patients.
Journal ArticleDOI
Lack of association of OPRM1 and ABCB1 single-nucleotide polymorphisms to oxycodone response in postoperative pain.
Stine Thorhauge Zwisler,Stine Thorhauge Zwisler,Thomas P. Enggaard,Thomas P. Enggaard,Soeren Mikkelsen,Céline Verstuyft,Laurent Becquemont,Soeren H. Sindrup,Kim Brøsen +8 more
TL;DR: No association was found between the tested single‐nucleotide polymorphisms in OPRM1 and ABCB1 and changes in the analgesic effect of oxycodone in postoperative pain.