S
Sun Dongbang
Researcher at Korea University
Publications - 5
Citations - 671
Sun Dongbang is an academic researcher from Korea University. The author has contributed to research in topics: Prodrug & Camptothecin. The author has an hindex of 3, co-authored 4 publications receiving 569 citations. Previous affiliations of Sun Dongbang include University of Connecticut.
Papers
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Journal ArticleDOI
Disulfide-cleavage-triggered chemosensors and their biological applications.
Journal ArticleDOI
Camptothecin delivery into hepatoma cell line by galactose-appended fluorescent drug delivery system
Sun Dongbang,Hyun Mi Jeon,Min Hee Lee,Weon Sup Shin,Joon Kook Kwon,Chulhun Kang,Jong Seung Kim +6 more
TL;DR: A galactose-appended camptothecin prodrug was newly synthesized and preferentially entered a hepatoma cell line and the drug release triggered by disulfide-bond cleavage via reaction with glutathione was visualized on the basis of fluorescence changes of the naphthalimide moiety.
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Asymmetric synthesis of (−)-naltrexone
TL;DR: The asymmetric synthesis of (–)-naltrexone was achieved by a Rh(i)-catalyzed C–H alkenylation and torquoselective electrocyclization cascade and late-stage C-H hydroxylation.
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Ni/Photoredox-Catalyzed C(sp3)-C(sp3) Coupling between Aziridines and Acetals as Alcohol-Derived Alkyl Radical Precursors.
Sun Dongbang,Abigail G. Doyle +1 more
TL;DR: In this article , a Ni/photoredox methodology for C(sp3)-C(sp 3) cross-coupling between aziridines and methyl/1°/2° aliphatic alcohols activated as benzaldehyde dialkyl acetals is presented.
Journal ArticleDOI
HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery
Hoyeon Lee,Soojin Uhm,Jung Won Shin,Hyun Mi Jeon,Sun Dongbang,Hyo Sung Jung,Yun-Cheol Na,Chulhun Kang,Jong Seung Kim +8 more
TL;DR: It is found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy.