Artin Mahboubi

TL;DR: It is shown, using a cell-free system, that Hsp70 prevents cytochrome c/dATP-mediated caspase activation, but allows the formation of Apaf-1 oligomers, which suppresses apoptosis by directly associating with Apf-1 and blocking the assembly of a functional apoptosome.

TL;DR: This work shows that the Fas/CD95 receptor, which can transduce a potent apoptotic signal when ligated, is rapidly expressed following activation of T-cell hybridomas, as is its functional, membrane-bound ligand8.

TL;DR: It is demonstrated that Bcl-2 prevents apoptotic death induced by c-Myc, a mechanism whereby cells can express c- myc without undergoing apoptosis is provided, and a possible explanation for the ability of B cl-2 to synergize with c-myc in cell transformation is given.

TL;DR: It is reported that activation of the two transcription factors NF-kappa B and AP-1 is crucially involved in FasL expression induced by etoposid, teniposide, and UV irradiation and contributes to stress-induced apoptosis via the expression of FasL.

TL;DR: This chapter describes cell death assays that are based on the observation that apoptosis is accompanied by DNA fragmentation, either into the classical “ladder” pattern of 200 bp integer multiples, 50kb fragments, or single-stranded DNA cleavage.