Sung-Eun Kim

TL;DR: It is proposed that formation of the TLR1-TLR2 heterodimer brings the intracellular TIR domains close to each other to promote dimerization and initiate signaling.

TL;DR: A model ofTLR4-MD-2 dimerization induced by LPS is proposed and a series of hybrids of human TLR4 and hagfish VLR are produced and their structures with and without bound MD-2 and Eritoran are determined.

TL;DR: It is shown that Drosophila melanogaster Piezo (DmPiezo, also called CG8486) also induces mechanically activated currents in cells, but through channels with remarkably distinct pore properties including sensitivity to the pore blocker ruthenium red and single channel conductances, demonstrating that Piezo proteins are an evolutionarily conserved ion channel family involved in mechanotransduction.

TL;DR: The physiological relevance of the Piezo family in mechanotransduction in vivo is demonstrated, supporting a role of Piezo proteins in mechanosensory nociception.

TL;DR: It is proposed that sequential occupancy of short and long open states on activation provides a mechanism for enhancing temperature sensitivity and is suggested that the outer pore is important for the heat sensitivity of thermoTRPs.