Mauricio Montal

TL;DR: Monte Carlo simulations demonstrate that folding funnel calculations accurately predict the fact of and the pathways involved in folding-specific sequences, and suggest that geometrically related families of stable, collapsed conformers fulfill kinetic and thermodynamic requirements of protein folding.

TL;DR: Early mitochondrial damage plays a key role in induction of glutamate neurotoxicity, and blockade of the mitochondrial permeability transition pore by cyclosporin A allows complete recovery of ΔΨ and prevents cell death.

TL;DR: It is shown that Drosophila melanogaster Piezo (DmPiezo, also called CG8486) also induces mechanically activated currents in cells, but through channels with remarkably distinct pore properties including sensitivity to the pore blocker ruthenium red and single channel conductances, demonstrating that Piezo proteins are an evolutionarily conserved ion channel family involved in mechanotransduction.

TL;DR: In this paper, the pore-forming domains of Bcl-2 proteins were compared to those of diphtheria toxin and colicins, suggesting a novel function for this anti-apoptotic protein.

TL;DR: Biophysical evidence that Bcl-2 forms channels in lipid membranes is provided, suggesting a novel function for this antiapoptotic protein.