S
Sung Hee Baek
Researcher at Seoul National University
Publications - 122
Citations - 15508
Sung Hee Baek is an academic researcher from Seoul National University. The author has contributed to research in topics: Ubiquitin & Ubiquitin ligase. The author has an hindex of 46, co-authored 113 publications receiving 13362 citations. Previous affiliations of Sung Hee Baek include UPRRP College of Natural Sciences & Howard Hughes Medical Institute.
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Journal ArticleDOI
Negative Modulation of RXRα Transcriptional Activity by Small Ubiquitin-related Modifier (SUMO) Modification and Its Reversal by SUMO-specific Protease SUSP1
Soo Joon Choi,Sung Soo Chung,Eun Jung Rho,Hyungwoo Lee,Moon Hee Lee,Heung Sik Choi,Jae Hong Seol,Sung Hee Baek,Ok Sun Bang,Chin Ha Chung +9 more
TL;DR: It is demonstrated that RXRα is a target substrate of a small ubiquitin-related modifier (SUMO)-specific protease, SUSP1, which is capable of controlling the transcriptional activity of RXRβ and thus in the RXR α-mediated cellular processes.
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SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination
Moon Hee Lee,Sungwon Lee,Eun-Joo Lee,Soo Joon Choi,Sung Soo Chung,Jae Il Lee,Joong Myung Cho,Jae Hong Seol,Sung Hee Baek,Keun Il Kim,Tomoki Chiba,Keiji Tanaka,Ok Sun Bang,Chin Ha Chung +13 more
TL;DR: A new mechanism is established for the elevation of cellular p53 levels in response to UV damage, driven by a new SUMO-specific protease and a new desumoylation in Mdm2, which promotes p53 self-ubiquitination and degradation.
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UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction.
TL;DR: It is found that UCH-L1 is specifically highly expressed in the metastatic DU145 prostate cancer cell line, but not in the benign or weakly metastatic prostate cancer cells, indicating that this enzyme could be a novel diagnostic and therapeutic target for prostate cancer treatment.
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Roles of Mis18α in Epigenetic Regulation of Centromeric Chromatin and CENP-A Loading
Ik Soo Kim,Minkyoung Lee,Koog Chan Park,Yoon Kyung Jeon,Joo Hyeon Park,Eun Ju Hwang,Eun Ju Hwang,Tae Im Jeon,Seoyoung Ko,Ho Lee,Sung Hee Baek,Keun Il Kim +11 more
TL;DR: It is found that Mis18α deficiency resulted in lethality at early embryonic stage with severe defects in chromosome segregation caused by mislocalization of CENP-A, and this interaction is critical for maintaining DNA methylation and hence regulating epigenetic states of centromeric chromatin.
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DNA Damage-Induced RORα Is Crucial for p53 Stabilization and Increased Apoptosis
Hyun-Kyung Kim,Ji Min Lee,Gina Lee,Jinhyuk Bhin,Se Kyu Oh,Kyeong Kyu Kim,Ki Eun Pyo,Jason Sang Hun Lee,Hwa Young Yim,Keun Il Kim,Daehee Hwang,Jongkyeong Chung,Sung Hee Baek +12 more
TL;DR: It is determined that RORα is a p53 regulator that exerts its role in increased apoptosis via p53, and enhances p53-dependent, in vivo apoptotic function in the Drosophila model system.