S
Sung Hee Baek
Researcher at Seoul National University
Publications - 122
Citations - 15508
Sung Hee Baek is an academic researcher from Seoul National University. The author has contributed to research in topics: Ubiquitin & Ubiquitin ligase. The author has an hindex of 46, co-authored 113 publications receiving 13362 citations. Previous affiliations of Sung Hee Baek include UPRRP College of Natural Sciences & Howard Hughes Medical Institute.
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Journal ArticleDOI
AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy
Hijai R. Shin,Hyun-Kyung Kim,Sungryong Oh,Jun Gi Lee,Minjung Kee,Hyun-Jeong Ko,Mi-Na Kweon,Kyoung-Jae Won,Sung Hee Baek +8 more
TL;DR: It is demonstrated that CARM1-dependent histone arginine methylation is a crucial nuclear event in autophagy, and a new signalling axis of AMPK–SKP2–CARM1 is identified in the regulation ofAutophagy induction after nutrient starvation.
Journal ArticleDOI
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.
Jung Hwa Kim,Bogyou Kim,Ling Cai,Hee June Choi,Kenneth A. Ohgi,Chris Tran,Charlie Chen,Chin Ha Chung,Otmar Huber,David W. Rose,Charles L. Sawyers,Michael G. Rosenfeld,Sung Hee Baek +12 more
TL;DR: The molecular mechanisms underlying the antagonistic regulation of β-catenin–reptin and the Tip60 coactivator complexes for the metastasis suppressor gene, KAI1, are likely to be prototypic of a selective downregulation strategy for many genes, including a subset of NF-κB target genes.
Journal ArticleDOI
Macrophage/Cancer Cell Interactions Mediate Hormone Resistance by a Nuclear Receptor Derepression Pathway
Ping Zhu,Sung Hee Baek,Sung Hee Baek,Eliot Michael Bourk,Kenneth A. Ohgi,Ivan Garcia-Bassets,Hideki Sanjo,Shizuo Akira,Paul F. Kotol,Christopher K. Glass,Michael G. Rosenfeld,David W. Rose +11 more
TL;DR: Specific prostate cancer cell/macrophage interactions that mediate a switch in function of selective androgen receptor antagonists/modulators (SARMs) from repression to activation in vivo are reported.
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Promoter-Specific Roles for Liver X Receptor/Corepressor Complexes in the Regulation of ABCA1 and SREBP1 Gene Expression
Brandee L. Wagner,Annabel F. Valledor,Gang Shao,Chris L. Daige,Eric D. Bischoff,Mary Petrowski,Kristen Jepsen,Sung Hee Baek,Richard A. Heyman,Michael G. Rosenfeld,Ira G. Schulman,Christopher K. Glass +11 more
TL;DR: It is reported that high-density-lipoprotein (HDL) cholesterol levels are increased in LXR-deficient mice, suggesting that derepression of ABCA1 and possibly other LXR target genes in selected tissues is sufficient to result in enhanced HDL biogenesis at the whole-body level.
Journal ArticleDOI
EZH2 Generates a Methyl Degron that Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex
Ji Min Lee,Jason Sang Hun Lee,Hyun-Kyung Kim,Kyeongkyu Kim,Hye-Jin Park,Jiyoung Kim,Seung Hoon Lee,Ik Soo Kim,J. W. Kim,Minkyoung Lee,Chin Ha Chung,Sang Beom Seo,Jong Bok Yoon,Eunyoung Ko,Dong-Young Noh,Keun Il Kim,Kyeong Kyu Kim,Sung Hee Baek +17 more
TL;DR: It is proposed that EZH2-DCAF1/DDB1/CUL4 represents a previously unrecognized methylation-dependent ubiquitination machinery specifically recognizing "methyl degron"; through this, nonhistone protein stability can be dynamically regulated in a methylation -dependent manner.