Sung Hee Baek

TL;DR: Evidence is provided that lysine-specific demethylase 3A (KDM3A) functions as an essential epigenetic enzyme for the activation of JAK2−STAT3 signaling pathway, which is essential for modulating cellular development, differentiation, and homeostasis.

TL;DR: It is found that protein kinase M ζ is transported to the nucleus in a neural activity-dependent manner and it is shown that the amnesic effect of PKMζ inhibition can be rescued by enhancing histone acetylation level.

TL;DR: It is found that Pontin chromatin remodelling factor plays an essential role as a coactivator for Oct4 for maintenance of pluripotency in mouse ES cells, and the Oct4-Pontin module plays critical roles in the regulation of genes involved in ES cell fate determination.

TL;DR: The osteopenia phenotype of mice lacking Usp18 (also called Ubp43), which is a deISGylating enzyme and is known as a negative regulator of type I IFN signaling, is identified and it is suggested that, although type IIFN is known to restrict osteoclast differentiation, the exaggerated activation of the type II IFN response in Usp 18-knockout mice causes an oste Openia phenotype in mice.

TL;DR: A new physiologically relevant mechanism that regulates HIF-1α stability in the nucleus in response to cellular oxygen levels is identified, based on the collaboration between the SET7/9 methyltransferase and the LSD1 demethylase.