S
Sungkwon Chung
Researcher at Sungkyunkwan University
Publications - 72
Citations - 1908
Sungkwon Chung is an academic researcher from Sungkyunkwan University. The author has contributed to research in topics: Patch clamp & Substantia nigra. The author has an hindex of 24, co-authored 72 publications receiving 1697 citations. Previous affiliations of Sungkwon Chung include Northwestern University & Chung-Ang University.
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Journal ArticleDOI
Presenilin-mediated modulation of capacitative calcium entry.
Andrew S. Yoo,Isaac Cheng,Sungkwon Chung,Tallessyn Z. Grenfell,Hanmi Lee,Eunju Pack-Chung,Melissa Handler,Jie Shen,Weiming Xia,Giuseppina Tesco,Aleister J. Saunders,Kai Ding,Matthew P. Frosch,Rudolph E. Tanzi,Tae-Wan Kim +14 more
TL;DR: Reduced CCE is most likely an early cellular event leading to increased Abeta42 generation associated with FAD mutant presenilins, indicating that the CCE pathway is a novel therapeutic target for Alzheimer's disease.
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Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism.
Natalie Landman,Soon Youn Jeong,Sun Young Shin,Sergey V. Voronov,Geo Serban,Min Suk Kang,Myung Kyu Park,Gilbert Di Paolo,Sungkwon Chung,Tae-Wan Kim +9 more
TL;DR: The data suggest that PIP2 imbalance may contribute to Alzheimer's disease pathogenesis by affecting multiple cellular pathways, such as the generation of toxic Aβ42 as well as the activity of the MIC/TRPM7 channel, which has been linked to other neurodegenerative conditions.
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The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease
Na-Young Bae,Taek-Won Ahn,Sungkwon Chung,Myung Sook Oh,Hyeonseok Ko,Hyungun Oh,Gunhyuk Park,Hyun Ok Yang +7 more
TL;DR: Modified Yeoldahanso-tang treatment has neuroprotective effects that are partially mediated by autophagy enhancement that may be a promising herbal formula for the prevention and treatment of neurodegenerative diseases, especially PD.
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Effect of ginsenosides, active components of ginseng, on capsaicin-induced pain-related behavior.
TL;DR: The results suggest that ginsenosides produce antinociceptive effects through their action at the spinal and/or supraspinal site(s), not at nociceptors in the periphery, and that these effects are not mediated by opioid receptors.
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O-GlcNAcylation promotes non-amyloidogenic processing of amyloid-β protein precursor via inhibition of endocytosis from the plasma membrane.
Yoon Sun Chun,Yurim Park,Hyun Geun Oh,Tae-Wan Kim,Hyun Ok Yang,Myoung Kyu Park,Sungkwon Chung +6 more
TL;DR: O-GlcNAcylation promotes the plasma membrane localization of AβPP, which enhances the non-amyloidogenic processing of A βPP, and can be a potential therapeutic strategy for Alzheimer's disease.