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Aleister J. Saunders
Researcher at Drexel University
Publications - 67
Citations - 4517
Aleister J. Saunders is an academic researcher from Drexel University. The author has contributed to research in topics: Amyloid precursor protein & Cytochrome c peroxidase. The author has an hindex of 28, co-authored 66 publications receiving 4258 citations. Previous affiliations of Aleister J. Saunders include North Carolina State University & Harvard University.
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Journal ArticleDOI
Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity CORRELATION WITH CELL-FREE HYDROGEN PEROXIDE PRODUCTION AND METAL REDUCTION
Xudong Huang,Math P. Cuajungco,Craig S. Atwood,Mariana A. Hartshorn,Joel D. A. Tyndall,Graeme R. Hanson,Karen C. Stokes,Michael C. Leopold,Gerd Multhaup,Lee E. Goldstein,Richard C. Scarpa,Aleister J. Saunders,James Lim,Robert D. Moir,Charles G. Glabe,Edmond F. Bowden,Colin L. Masters,David P. Fairlie,Rudolph E. Tanzi,Ashley I. Bush +19 more
TL;DR: It is reported that Cu(II) markedly potentiates the neurotoxicity exhibited by Abeta in cell culture, suggesting that certain redox active metal ions may be important in exacerbating and perhaps facilitating Abeta-mediated oxidative damage in Alzheimer's disease.
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Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q
Lars Bertram,Deborah Blacker,Kristina Mullin,Devon Keeney,Jennifer A. Jones,Sanjay Basu,Stephen Yhu,Melvin G. McInnis,Rodney C.P. Go,Konstantinos Vekrellis,Dennis J. Selkoe,Aleister J. Saunders,Rudolph E. Tanzi +12 more
TL;DR: Evidence for allele-specific association between the putative disease locus and marker D10S583, which has recently been located within 195 kilobases of the IDE gene, is found.
Journal ArticleDOI
Results of a high-resolution genome screen of 437 Alzheimer's Disease families
Deborah Blacker,Lars Bertram,Aleister J. Saunders,T J Moscarillo,Marilyn S. Albert,Howard W. Wiener,Rodney T. Perry,Julianne S. Collins,Lindy E. Harrell,Rodney C.P. Go,Amy Mahoney,Terri H. Beaty,M. Danielle Fallin,Dimitrios Avramopoulos,Gary A. Chase,Marshal F. Folstein,Melvin G. McInnis,Susan Spear Bassett,Kimberly Doheny,Elizabeth W. Pugh,Rudolph E. Tanzi +20 more
TL;DR: Performing standard parametric and non-parametric linkage analyses, a 'highly significant' linkage peak by Lander and Kruglyak criteria on chromosome 19q13, which probably represents APOE is observed, which should provide a valuable framework for future studies aimed at identifying additional susceptibility genes for late-onset AD.
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Presenilin-mediated modulation of capacitative calcium entry.
Andrew S. Yoo,Isaac Cheng,Sungkwon Chung,Tallessyn Z. Grenfell,Hanmi Lee,Eunju Pack-Chung,Melissa Handler,Jie Shen,Weiming Xia,Giuseppina Tesco,Aleister J. Saunders,Kai Ding,Matthew P. Frosch,Rudolph E. Tanzi,Tae-Wan Kim +14 more
TL;DR: Reduced CCE is most likely an early cellular event leading to increased Abeta42 generation associated with FAD mutant presenilins, indicating that the CCE pathway is a novel therapeutic target for Alzheimer's disease.
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Interpreting the effects of small uncharged solutes on protein-folding equilibria.
TL;DR: Experimental advantage may still be taken of the ability of the cosolute effect to promote not only protein stabilization but also protein self-association and complex formation between dissimilar reactants.