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Sunil Agarwal
Researcher at Genentech
Publications - 19
Citations - 6007
Sunil Agarwal is an academic researcher from Genentech. The author has contributed to research in topics: Rituximab & Rheumatoid arthritis. The author has an hindex of 11, co-authored 19 publications receiving 5485 citations.
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Journal ArticleDOI
B-cell depletion with rituximab in relapsing-remitting multiple sclerosis.
Stephen L. Hauser,Emmanuelle Waubant,Douglas L. Arnold,Timothy Vollmer,Jack P. Antel,Robert J. Fox,Amit Bar-Or,Michael Panzara,Neena Sarkar,Sunil Agarwal,Annette Langer-Gould,Craig H. Smith +11 more
TL;DR: A single course of rituximab reduced inflammatory brain lesions and clinical relapses for 48 weeks and provides evidence of B-cell involvement in the pathophysiology of relapsing-remitting multiple sclerosis.
Journal ArticleDOI
The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial.
Paul Emery,Roy Fleischmann,Anna Filipowicz-Sosnowska,Joy Schechtman,Leszek Szczepanski,Arthur Kavanaugh,Artur Racewicz,Ronald F van Vollenhoven,Nicole F. Li,Sunil Agarwal,E. W. Hessey,T. Shaw +11 more
TL;DR: Both rituximab doses were effective and well tolerated when added to MTX therapy in patients with active rheumatoid arthritis, although intravenous glucocorticoid premedication improved tolerability during the first ritUXimab infusion.
Journal ArticleDOI
Omalizumab for the Treatment of Chronic Idiopathic or Spontaneous Urticaria
Marcus Maurer,Karin Rosén,Hsin-Ju Hsieh,Sarbjit S. Saini,Clive Grattan,Ana Giménez-Arnau,Sunil Agarwal,Ramona Doyle,Janice Canvin,Allen P. Kaplan,Thomas B. Casale +10 more
TL;DR: Omalizumab diminished clinical symptoms and signs of chronic idiopathic urticaria in patients who had remained symptomatic despite the use of approved doses of H-antihistamine therapy (licensed doses).
Journal ArticleDOI
Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial
Cem Gabay,Paul Emery,Ronald F van Vollenhoven,Ara Dikranian,Rieke Alten,Karel Pavelka,Micki Klearman,David Musselman,Sunil Agarwal,Jennifer Green,Arthur Kavanaugh +10 more
TL;DR: Tocilizumab monotherapy was superior to adalimumabmonotherapy for reduction of signs and symptoms of rheumatoid arthritis in patients for whom methotrexate was deemed inappropriate.
Journal ArticleDOI
Rituximab in relapsing-remitting multiple sclerosis: a 72-week, open-label, phase I trial.
Amit Bar-Or,Peter A. Calabresi,Douglas L. Arnold,Clyde E. Markowitz,Stuart Shafer,Lloyd H. Kasper,Emmanuelle Waubant,Suzanne Gazda,Robert J. Fox,Michael Panzara,Neena Sarkar,Sunil Agarwal,Craig H. Smith +12 more
TL;DR: An apparent reduction in relapses was also observed over the 72 weeks compared with the year before therapy, and events were limited to mild‐to‐moderate infusion‐associated events, which tended to decrease with subsequent infusions.