S
Surendra Dasari
Researcher at Mayo Clinic
Publications - 258
Citations - 8783
Surendra Dasari is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Medicine & Amyloidosis. The author has an hindex of 42, co-authored 193 publications receiving 6243 citations. Previous affiliations of Surendra Dasari include University of Rochester & Vanderbilt University Medical Center.
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Journal ArticleDOI
CPAT: Coding-Potential Assessment Tool using an alignment-free logistic regression model
TL;DR: A novel alignment-free method, Coding Potential Assessment Tool (CPAT), which rapidly recognizes coding and noncoding transcripts from a large pool of candidates, and is approximately four orders of magnitude faster than Coding-Potential Calculator and Phylo Codon Substitution Frequencies.
Journal ArticleDOI
IDPicker 2.0: Improved protein assembly with high discrimination peptide identification filtering.
Ze Qiang Ma,Surendra Dasari,Matthew C. Chambers,Michael D. Litton,Scott M. Sobecki,Lisa J. Zimmerman,Patrick J. Halvey,Birgit Schilling,Penelope M. Drake,Bradford W. Gibson,David L. Tabb +10 more
TL;DR: The new version of IDPicker is more robust against false positive proteins, especially in searches using multispecies databases, by requiring additional novel peptides in the parsimony process.
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Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans
Matthew M. Robinson,Surendra Dasari,Adam R. Konopka,Matthew L. Johnson,Shankarappa Manjunatha,Raul Ruiz Esponda,Rickey E. Carter,Ian R. Lanza,K. Sreekumaran Nair +8 more
TL;DR: It is reported that 12 weeks of high-intensity aerobic interval (HIIT), resistance (RT), and combined exercise training enhanced insulin sensitivity and lean mass, but only HIIT and combined training improved aerobic capacity and skeletal muscle mitochondrial respiration.
Journal ArticleDOI
Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility?
P.A. Wilmarth,S Tanner,Surendra Dasari,Srinivasa R. Nagalla,Michael A. Riviere,Vineet Bafna,Pavel A. Pevzner,Larry L. David +7 more
TL;DR: This work employed recently developed blind modification search techniques to generate the most comprehensive map of post-translational modifications in human lens constructed to date and found that the extent of deamidation was significantly increased in the water-insoluble fractions of the aged lenses.
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Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis.
Ian R. Lanza,Piotrek Zabielski,Katherine A. Klaus,Dawn M. Morse,Carrie J. Heppelmann,H. Robert Bergen,Surendra Dasari,Stephane Walrand,Kevin R. Short,Matthew L. Johnson,Matthew M. Robinson,Jill M. Schimke,Daniel R. Jakaitis,Yan W. Asmann,Zhifu Sun,K. Sreekumaran Nair +15 more
TL;DR: It is found that CR decreases oxidant emission, increases antioxidant scavenging, and minimizes oxidative damage to DNA and protein, which demonstrates that CR preserves mitochondrial function by protecting the integrity and function of existing cellular components rather than by increasing mitochondrial biogenesis.