S
Suresh K. Rayala
Researcher at Indian Institute of Technology Madras
Publications - 93
Citations - 3952
Suresh K. Rayala is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Cancer & Kinase. The author has an hindex of 34, co-authored 90 publications receiving 3625 citations. Previous affiliations of Suresh K. Rayala include University of Texas Health Science Center at Houston & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
MicroRNA-7, a Homeobox D10 Target, Inhibits p21-Activated Kinase 1 and Regulates Its Functions
TL;DR: It is established for the first time that Pak1 is a target of microRNA-7 and that HoxD10 plays a regulatory role in modifying the expression of miR- 7 and, consequently, the functions of themiR-7-Pak1 pathway in human cancer cells are established.
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Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions.
TL;DR: It is found for the first time that Pak1 promotes transcription repression activity of Snail from E-cadherin, occludin, and aromatase promoters and represents a novel mechanism by which a signaling kinase might contribute to the process of epithelial-mesenchymal transition.
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Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features.
Mahitosh Mandal,J.N. Myers,Scott M. Lippman,Faye M. Johnson,Michelle D. Williams,Suresh K. Rayala,Kazufumi Ohshiro,David I. Rosenthal,Randal S. Weber,Gary E. Gallick,Adel K. El-Naggar +10 more
TL;DR: The expressions of several factors associated with the induction of EMT in HNSC cell lines and tumor specimens were investigated to define their functional and pathologic role in HnSC.
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PAK Signaling in Oncogenesis
TL;DR: The complex regulation of PAK and its downstream diverse myriads of effectors, which in turn are responsible for the biological effects ofPAK family of kinases in cancer cells are summarized.
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Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients.
TL;DR: A role for Pak1, particular Pak1 localized to the nucleus, in ERalpha signaling and in tamoxifen resistance is supported, suggesting that tamoxIFen, to some extent, regulates Pak1 expression.