S
Suresh K. Rayala
Researcher at Indian Institute of Technology Madras
Publications - 93
Citations - 3952
Suresh K. Rayala is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Cancer & Kinase. The author has an hindex of 34, co-authored 90 publications receiving 3625 citations. Previous affiliations of Suresh K. Rayala include University of Texas Health Science Center at Houston & University of Texas MD Anderson Cancer Center.
Papers
More filters
Journal ArticleDOI
Importance of functional groups in predicting the activity of small molecule inhibitors for Bcl-2 and Bcl-xL.
TL;DR: This study predicted the factors driving differential activity and specificity implementing multiplexed QSAR analysis for a dataset of 1,649 reported inhibitors of Bcl‐2 (B‐cell lymphoma‐2) and B cl‐xL (B-cell lymphomas‐extra large) and critically analyzed the chemical space with coupling factors.
Journal ArticleDOI
Solution structure and antiestrogenic activity of the unique C-terminal, NR-box motif-containing region of MTA1s.
Rajesh R. Singh,Kumaralal Kaluarachchi,Mingzhi Chen,Suresh K. Rayala,Seetharaman Balasenthil,Jianpeng Ma,Jianpeng Ma,Rakesh Kumar,Rakesh Kumar +8 more
TL;DR: The characterization of structure and antiestrogenic activity of MTA1s peptide highlight its therapeutic potential and finds a predominance of the α-helical region toward the N-terminal region, which includes the NR-box motif.
Journal ArticleDOI
Altered localization of a coactivator sensitizes breast cancer cells to tumor necrosis factor–induced apoptosis
TL;DR: It is found that clones of MCF-7 human breast cancer cells overexpressing PELP1 in the cytoplasm were distinctly sensitive to TNF-α-induced apoptosis, paving the way for developing new treatment strategies for tumors with cy toplasmic P ELP1 expression.
Journal ArticleDOI
Snail-Modulated MicroRNA 493 Forms a Negative Feedback Loop with the Insulin-Like Growth Factor 1 Receptor Pathway and Blocks Tumorigenesis.
Arathy S. Kumar,Sankar Jagadeeshan,Ravi Shankar Pitani,Vijayalakshmi Ramshankar,Kesavan Venkitasamy,Ganesh Venkatraman,Suresh K. Rayala +6 more
TL;DR: The study showed that nicotine treatment significantly decreases the levels of miR-493—with a concomitant increase in the Levels of Snail—an indication of progression of cells toward tumorigenesis, reestablishing the role of tobacco as a major risk factor for head and neck cancers and elucidating the mechanism behind nicotine-mediated tumorigenisation.
Journal ArticleDOI
Identification of a Novel Estrogen Receptor-α Variant and Its Upstream Splicing Regulator
Kazufumi Ohshiro,Prakriti Mudvari,Qing Chang Meng,Suresh K. Rayala,Aysegul A. Sahin,Suzanne A. W. Fuqua,Rakesh Kumar +6 more
TL;DR: A role for NPE3-3 in alternative splicing is revealed and it is suggested that ERalpha is a physiological target of NPE2-3, leading to a constitutive nongenomic signaling pathway in breast cancer cells.