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Stephen C. Benoit
Researcher at University of Cincinnati
Publications - 154
Citations - 12513
Stephen C. Benoit is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Insulin & Energy homeostasis. The author has an hindex of 58, co-authored 154 publications receiving 11716 citations. Previous affiliations of Stephen C. Benoit include Purdue University & University of Cincinnati Academic Health Center.
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Journal ArticleDOI
Ghrelin controls hippocampal spine synapse density and memory performance
Sabrina Diano,Susan A. Farr,Susan A. Farr,Stephen C. Benoit,Ewan C. McNay,Ivaldo Silva,Balazs Horvath,F. Spencer Gaskin,F. Spencer Gaskin,Naoko Nonaka,Naoko Nonaka,Laura B. Jaeger,Laura B. Jaeger,William A. Banks,William A. Banks,John E. Morley,John E. Morley,Shirly Pinto,Robert S. Sherwin,Lin Xu,Kelvin A. Yamada,Mark W. Sleeman,Matthias H. Tschöp,Tamas L. Horvath +23 more
TL;DR: It is reported that circulating ghrelin enters the hippocampus and binds to neurons of the hippocampal formation, where it promotes dendritic spine synapse formation and generation of long-term potentiation.
Journal ArticleDOI
IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation
Hak-Ling Ma,Spencer Liang,Jing Li,Lee Napierata,Tom Brown,Stephen C. Benoit,Mayra Senices,Davinder Gill,Kyriaki Dunussi-Joannopoulos,Mary Collins,Cheryl Nickerson-Nutter,Lynette A. Fouser,Deborah A. Young +12 more
TL;DR: It is proposed that IL-22 antagonism might be a promising therapy for the treatment of human psoriasis, which is induced by the transfer of CD4(+)CD45RB(hi)CD25(-) cells to pathogen-free scid/scid mice.
Journal ArticleDOI
Gonadal Hormones Determine Sensitivity to Central Leptin and Insulin
TL;DR: It is indicated that estrogen acts within the brain to increase leptin sensitivity, decrease insulin sensitivity, and favor subcutaneous over visceral fat.
Journal ArticleDOI
The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins
Stephen C. Benoit,Ellen L. Air,Lique M. Coolen,Richelle Strauss,Alana Jackman,Deborah J. Clegg,Randy J. Seeley,Stephen C. Woods +7 more
TL;DR: The data suggest that the hypothalamic melanocortin system mediates the anorexic effects of central insulin, as well as of leptin.
Journal ArticleDOI
The central melanocortin system directly controls peripheral lipid metabolism
Rubén Nogueiras,Petra Wiedmer,Diego Perez-Tilve,Christelle Veyrat-Durebex,Julia M. Keogh,Gregory M. Sutton,Paul T. Pfluger,Tamara R. Castañeda,Susanne Neschen,Susanna M. Hofmann,Philip N. Howles,Donald A. Morgan,Stephen C. Benoit,Ildiko Szanto,Brigitte Schrott,Annette Schürmann,Hans-Georg Joost,Craig Hammond,David Y. Hui,Stephen C. Woods,Kamal Rahmouni,Andrew A. Butler,I. Sadaf Farooqi,Stephen O'Rahilly,Françoise Rohner-Jeanrenaud,Matthias H. Tschöp +25 more
TL;DR: Pharmacological inhibition of melanocortin receptors in rats and genetic disruption of Mc4r in mice directly and potently promoted lipid uptake, triglyceride synthesis, and fat accumulation in white adipose tissue (WAT), while increased CNS-Mcr signaling triggered lipid mobilization.