Susana B. Zanello

TL;DR: The HDT BR duration may be critical for replicating microgravity-related ophthalmologic changes observed in astronauts on ≥6-month spaceflights, suggesting that time may affect the amount of optic disc swelling.

TL;DR: A few functional and structural changes were detected after 14-d HDTBR, notably an improved BCVA possibly due to learning effect and RNFL thickening without signs of optic disc edema, and further studies with different BR duration and/or tilt angle are warranted to investigate microgravity-induced ophthalmological changes.

TL;DR: Ocular changes occurring in a healthy human subject enrolled in a bed rest study designed to replicate the effects of a low-gravity environment were documented after prolonged head-down BR, and changes may be related to cephalad fluid shifts in response to tilt.

TL;DR: Long-duration head-down tilt bed rest provided a suitable platform for examining physiologic effects of spaceflight and testing countermeasures in a ground-based model.

TL;DR: In this paper, the authors tested the hypothesis that retinal vascular remodeling, particularly by smaller vessels, mediates the chronic headward fluid shifts associated with SANS and found significant postflight decreases in Df, Lv, and in smaller but not larger vessels were quantified in 11 of 16 retinas for arteries and veins.